INT166107

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 6.04
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFSF10) extracellular space (TNFSF10) extracellular region (TNFSF10)
cell-cell signaling (TNFSF10)
Anatomy Link Frequency
aortas 2
anterior 2
TNFSF10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 3 89.60 High High
Inflammation 96 76.92 Quite High
cytokine 43 56.92 Quite High
Snapping jaw 1 50.00 Quite Low
Kinase C 30 5.00 Very Low Very Low Very Low
bradykinin 9 5.00 Very Low Very Low Very Low
spinal inflammation 6 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 360 100.00 Very High Very High Very High
Targeted Disruption 5 99.86 Very High Very High Very High
Ovarian Cancer 1 99.56 Very High Very High Very High
Diabetes Mellitus 249 99.20 Very High Very High Very High
Acute Promyelocytic Leukemia 1 98.28 Very High Very High Very High
Cancer 180 97.88 Very High Very High Very High
Death 66 94.48 High High
Multiple Myeloma 1 92.32 High High
Cv General 3 Under Development 3 89.60 High High
Cardiovascular Disease 24 88.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: The present study investigated, through immunohistochemistry, the regional expression of TRAIL and in temporomandibular joint (TMJ) disc of anterior disc displacement with reduction (ADDwR) and without reduction (ADDwoR) patients, to help determine the relationship between TMJ disc displacement and apoptosis.
Neg (without) Negative_regulation (reduction) of Spec (investigated) Gene_expression (expression) of TRAIL in anterior
1) Confidence 0.39 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20123409 Disease Relevance 0.09 Pain Relevance 0
These findings suggest that the downregulation of TRAIL expression may play a role in diabetic vasculopathy.
Negative_regulation (downregulation) of Gene_expression (expression) of TRAIL associated with diabetes mellitus
2) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.99 Pain Relevance 0.07
This showed the same result: a decrease of surface TRAIL expression.
Negative_regulation (decrease) of Gene_expression (expression) of TRAIL
3) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.98 Pain Relevance 0.08
The next remarkable observation in this study was the ability of insulin to downregulate TRAIL expression in rat aortas in vivo.
Negative_regulation (downregulate) of Gene_expression (expression) of TRAIL in aortas
4) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.18 Pain Relevance 0.11
Consistent with our data, TRAIL induced apoptosis is inhibited by IL8 in ovarian cancer cells [54], [55], by IL-1?
Negative_regulation (inhibited) of Gene_expression (apoptosis) of TRAIL associated with ovarian cancer and apoptosis
5) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.54 Pain Relevance 0
Indeed, in a transgenic mouse model defective in TRAIL receptor expression, treatment with valproic acid (HDACi of Class I) induces overexpression of these receptors.
Negative_regulation (defective) of Gene_expression (expression) of TRAIL associated with targeted disruption
6) Confidence 0.05 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 1.26 Pain Relevance 0

General Comments

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