INT166115

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Context Info
Confidence 0.61
First Reported 2002
Last Reported 2010
Negated 6
Speculated 2
Reported most in Body
Documents 42
Total Number 50
Disease Relevance 31.00
Pain Relevance 20.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1) plasma membrane (Lpar1) cytoplasm (Lpar1)
signal transducer activity (Lpar1)
Anatomy Link Frequency
nerve 16
dorsal root 10
spinal cord 4
epithelial cells 4
dorsal horn 3
Lpar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 885 100.00 Very High Very High Very High
Neuropathic pain 671 99.80 Very High Very High Very High
spinal dorsal horn 142 99.80 Very High Very High Very High
intrathecal 162 99.64 Very High Very High Very High
dorsal root ganglion 116 99.64 Very High Very High Very High
Sciatic nerve 449 99.40 Very High Very High Very High
Demyelination 584 99.12 Very High Very High Very High
primary afferent fibers 7 98.00 Very High Very High Very High
agonist 131 97.32 Very High Very High Very High
Dorsal horn 113 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 425 99.98 Very High Very High Very High
Targeted Disruption 142 99.98 Very High Very High Very High
Ovarian Cancer 215 99.86 Very High Very High Very High
Cancer 269 99.84 Very High Very High Very High
Neuropathic Pain 926 99.80 Very High Very High Very High
Pressure And Volume Under Development 16 99.76 Very High Very High Very High
Systemic Sclerosis 16 99.68 Very High Very High Very High
Ganglion Cysts 294 99.64 Very High Very High Very High
Demyelinating Disease 652 99.12 Very High Very High Very High
Injury 224 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, all the findings in the present report suggest that nerve injury-induced LPA production mainly occurs through LPC conversion mediated by activation of ATX.
Positive_regulation (induced) of Gene_expression (production) of LPA in nerve associated with nervous system injury
1) Confidence 0.61 Published 2008 Journal Mol Pain Section Body Doc Link PMC2277392 Disease Relevance 0.99 Pain Relevance 0.63
However, all the findings in the present report suggest that nerve injury-induced LPA production mainly occurs through LPC conversion mediated by activation of ATX.
Positive_regulation (occurs) of Gene_expression (production) of LPA in nerve associated with nervous system injury
2) Confidence 0.61 Published 2008 Journal Mol Pain Section Body Doc Link PMC2277392 Disease Relevance 0.99 Pain Relevance 0.64
In contrast, the increase observed in atx+/- mice was severely limited, suggesting that LPC-induced LPA production largely depends on the ATX action in vivo.
Positive_regulation (-) of Gene_expression (production) of LPA
3) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.19 Pain Relevance 0.21
This result is consistent with previous reports suggesting that LPA2 and LPA3 receptors might contribute to LPA-induced LPA production in ovarian cancer cells, because ovarian cancer cells express high levels of LPA2 and LPA3 receptors whereas normal ovarian epithelial cells express low levels of LPA2 and LPA3 receptors [41-43].
Positive_regulation (induced) of Gene_expression (production) of LPA-induced in epithelial cells associated with ovarian cancer
4) Confidence 0.60 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.48 Pain Relevance 0.38
These observations are in a good contrast with the previous findings that the nerve injury-induced activation of LPA1 receptor and RhoA causes functional changes in myelinated A-fibers, such as demyelination and up-regulation of Ca2+ channel ?
Positive_regulation (activation) of Gene_expression (receptor) of LPA1 in nerve associated with demyelination and nervous system injury
5) Confidence 0.50 Published 2006 Journal Mol Pain Section Body Doc Link PMC1562366 Disease Relevance 1.17 Pain Relevance 0.97
Therefore, targeted inhibition of ATX-mediated LPA biosynthesis as well as LPA1 receptor and its downstream pathways may represent a novel way to prevent nerve injury-induced neuropathic pain.



Positive_regulation (mediated) of Gene_expression (biosynthesis) of LPA1 receptor in nerve associated with nervous system injury and neuropathic pain
6) Confidence 0.50 Published 2008 Journal Mol Pain Section Body Doc Link PMC2277392 Disease Relevance 1.03 Pain Relevance 0.66
In the sham-operated Lpar1-/- mice, on the other hand, neither control treatment nor A?
Positive_regulation (operated) of Gene_expression (operated) of Lpar1
7) Confidence 0.50 Published 2008 Journal Mol Pain Section Body Doc Link PMC2599895 Disease Relevance 0.18 Pain Relevance 0.21
Although there are a few cell lines that do not respond to LPA with Ca2+ transients (RH7777 and B103) and although heterologous overexpression of LPA1,2,3,4,5 in these cell lines conveys LPA-elicited Ca2+ responses, these cells still express low levels of LPA GPCR transcripts and show endogenous signalling responses to LPA (Valentine et al., 2008b).
Positive_regulation (overexpression) of Gene_expression (overexpression) of LPA1
8) Confidence 0.45 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0
However, only the lpa1 receptor gene is expressed in both DRG neurons and dorsal root [73].
Positive_regulation (expressed) of Gene_expression (expressed) of lpa1 receptor in dorsal root associated with dorsal root ganglion
9) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.50 Pain Relevance 0.91
Therefore, targeted inhibition of ATX-mediated LPA biosynthesis as well as LPA1 receptor and its downstream pathways may represent a novel way to prevent nerve injury-induced neuropathic pain.



Positive_regulation (mediated) of Gene_expression (biosynthesis) of LPA in nerve associated with nervous system injury and neuropathic pain
10) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2277392 Disease Relevance 1.03 Pain Relevance 0.66
Regarding the proposal that LPA involved in the dorsal root demyelination comes from the spinal dorsal horn, we have reported that the intense stimulation of spinal dorsal horn in vitro causes de novo production of LPA [29].
Positive_regulation (causes) of Gene_expression (production) of LPA in dorsal horn associated with demyelination and spinal dorsal horn
11) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2989310 Disease Relevance 1.16 Pain Relevance 0.91
In vitro evidence for LPA-induced LPA production through ATX and LPA3 receptors
Positive_regulation (for) of Gene_expression (production) of LPA-induced
12) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.28
In vitro evidence for LPA-induced LPA production through ATX and LPA3 receptors
Positive_regulation (through) of Gene_expression (production) of LPA
13) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.28
LPA-induced LPA production was also entirely absent in Lpar3-/- mice (Fig. 3c and 3d).


Positive_regulation (absent) of Neg (absent) Gene_expression (production) of LPA
14) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.31
LPC-induced LPA production in the SC and DR was attenuated in atx+/- mice at 1 h after LPC treatment, compared with WT mice (Fig. 2a).
Positive_regulation (induced) of Gene_expression (production) of LPA associated with spinal cord
15) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.18 Pain Relevance 0.31
In vitro evidence for LPA-induced LPA production through ATX and LPA3 receptors
Positive_regulation (through) of Gene_expression (production) of LPA-induced
16) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.28
In vitro evidence for LPA-induced LPA production through ATX and LPA3 receptors
Positive_regulation (evidence) of Gene_expression (production) of LPA
17) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.28
I.t. injection of LPA (1 nmol) caused a time-dependent increase in LPA levels in the SC and DR that lasted until 3 h post-treatment, followed by a slight decline in LPA levels at 5 h.
Positive_regulation (increase) of Gene_expression (levels) of LPA associated with spinal cord
18) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.18 Pain Relevance 0.14
LPA-induced LPA production was also entirely absent in Lpar3-/- mice (Fig. 3c and 3d).


Positive_regulation (absent) of Neg (absent) Gene_expression (production) of LPA-induced
19) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0 Pain Relevance 0.32
ATX and LPA3 receptors are required in LPC-induced LPA production
Positive_regulation (induced) of Gene_expression (production) of LPA
20) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780384 Disease Relevance 0.18 Pain Relevance 0.30

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