INT166125

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.06
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
uterine 1
PHOSPHO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 97.12 Very High Very High Very High
cytokine 13 96.60 Very High Very High Very High
Pain 2 77.12 Quite High
Inflammatory response 3 75.00 Quite High
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Meningoencephalitis 8 99.24 Very High Very High Very High
Cancer 102 98.44 Very High Very High Very High
INFLAMMATION 10 97.12 Very High Very High Very High
Necrosis 18 95.16 Very High Very High Very High
Endometrial Cancer 40 88.72 High High
Metastasis 2 88.04 High High
Sprains And Strains 1 79.48 Quite High
Infection 2 78.32 Quite High
Acanthamoeba Keratitis 1 76.40 Quite High
Leiomyosarcoma 18 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The recent demonstration of elevated phospho-p70S6K and reduced phospho-AKT expression, indicative of mTOR (mammalian target of rapamycin) activation, in a group of extra-renal PEComas raises the possibility of using mTOR inhibitors such as rapamycin in the treatment of uterine PEComas and is another argument for their routine segregation [82].
Gene_expression (expression) of phospho in uterine
1) Confidence 0.75 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2278149 Disease Relevance 0.79 Pain Relevance 0
Anti-human PhosphoPlus Akt (Ser473), Akt, I?
Gene_expression (human) of Phospho
2) Confidence 0.65 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.56 Pain Relevance 0
Anti-human PhosphoPlus Akt (Ser473), Akt, I?
Gene_expression (Anti) of Phospho
3) Confidence 0.65 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.56 Pain Relevance 0
We show that the expressions of TLR4, myeloid differentiation protein 88 (MyD88), nuclear factor (NF)-kappaB, phospho-IkappaB, phospho-extracellular signal-regulated kinases 1/2 (p-Erk1/2) and the inflammatory cytokines interleukin (IL)-8, tumor necrosis factor (TNF)-alpha and interferon (IFN)-beta were significantly increased in Acanthamoeba-treated cells.
Gene_expression (expressions) of phospho-IkappaB associated with necrosis, inflammation, cancer, meningoencephalitis and cytokine
4) Confidence 0.04 Published 2010 Journal Immunol. Cell Biol. Section Abstract Doc Link 20125114 Disease Relevance 1.15 Pain Relevance 0.24

General Comments

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