INT166126

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Context Info
Confidence 0.54
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.67
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MYD88) signal transduction (MYD88) plasma membrane (MYD88)
intracellular (MYD88) cytoplasm (MYD88)
MYD88 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 2 99.14 Very High Very High Very High
Inflammation 176 95.28 Very High Very High Very High
cytokine 106 94.76 High High
chemokine 20 85.68 High High
antagonist 4 82.76 Quite High
tolerance 14 77.68 Quite High
Pain 2 77.12 Quite High
Inflammatory response 38 75.00 Quite High
agonist 108 62.60 Quite High
Inflammatory mediators 8 50.44 Quite High
Disease Link Frequency Relevance Heat
Meningoencephalitis 16 99.24 Very High Very High Very High
INFLAMMATION 210 98.98 Very High Very High Very High
Cancer 8 93.56 High High
Necrosis 10 93.32 High High
Infection 32 79.76 Quite High
Sprains And Strains 4 79.48 Quite High
Acanthamoeba Keratitis 2 76.40 Quite High
Diabetes Mellitus 36 63.48 Quite High
Endotoxemia 8 50.64 Quite High
Injury 68 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that the expressions of TLR4, myeloid differentiation protein 88 (MyD88), nuclear factor (NF)-kappaB, phospho-IkappaB, phospho-extracellular signal-regulated kinases 1/2 (p-Erk1/2) and the inflammatory cytokines interleukin (IL)-8, tumor necrosis factor (TNF)-alpha and interferon (IFN)-beta were significantly increased in Acanthamoeba-treated cells.
Gene_expression (expressions) of myeloid differentiation protein 88 associated with necrosis, inflammation, cancer, meningoencephalitis and cytokine
1) Confidence 0.54 Published 2010 Journal Immunol. Cell Biol. Section Abstract Doc Link 20125114 Disease Relevance 1.14 Pain Relevance 0.24
We show that the expressions of TLR4, myeloid differentiation protein 88 (MyD88), nuclear factor (NF)-kappaB, phospho-IkappaB, phospho-extracellular signal-regulated kinases 1/2 (p-Erk1/2) and the inflammatory cytokines interleukin (IL)-8, tumor necrosis factor (TNF)-alpha and interferon (IFN)-beta were significantly increased in Acanthamoeba-treated cells.
Gene_expression (expressions) of MyD88 associated with necrosis, inflammation, cancer, meningoencephalitis and cytokine
2) Confidence 0.54 Published 2010 Journal Immunol. Cell Biol. Section Abstract Doc Link 20125114 Disease Relevance 1.14 Pain Relevance 0.24
Human cholangiocytes express members of the let-7 miRNA family, at least one of which, let-7i, directly regulates TLR4 expression via a MyD88-NF-?
Gene_expression (expression) of MyD88
3) Confidence 0.27 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.13 Pain Relevance 0.19
This effect is mediated through the TLR4-PI3K-AKT signaling pathway, as the induction of inflammatory markers was also inhibited by a dominant-negative mutant of TLR4, MyD88, IRAK-1, TRAF6 or I?
Gene_expression (mutant) of MyD88 associated with inflammatory marker
4) Confidence 0.27 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.15 Pain Relevance 0.18
MyD88 and CD14 expression was not significantly altered following insulin infusion (data not shown).


Gene_expression (expression) of MyD88
5) Confidence 0.21 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.06 Pain Relevance 0
MyD88 and CD14 are essential proteins involved in TLR signal transduction and LPS binding; therefore, their expression following insulin infusion was also investigated.
Gene_expression (expression) of MyD88
6) Confidence 0.18 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.06 Pain Relevance 0

General Comments

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