INT166131

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.40
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col7a1) cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1)
Anatomy Link Frequency
spleen 2
fibroblasts 2
lung 2
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 13 100.00 Very High Very High Very High
Morphine 4 99.80 Very High Very High Very High
fibrosis 41 99.76 Very High Very High Very High
cytokine 37 99.76 Very High Very High Very High
Arthritis 97 99.60 Very High Very High Very High
Pain 1 97.88 Very High Very High Very High
Analgesic 3 97.28 Very High Very High Very High
Inflammation 149 94.32 High High
Inflammatory mediators 2 90.72 High High
antagonist 15 69.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 146 100.00 Very High Very High Very High
Osteoporosis 14 100.00 Very High Very High Very High
Pulmonary Fibrosis 12 99.76 Very High Very High Very High
Arthritis 103 99.60 Very High Very High Very High
Pain 1 97.88 Very High Very High Very High
Injury 18 97.68 Very High Very High Very High
Sprains And Strains 35 97.36 Very High Very High Very High
Immunization 18 97.20 Very High Very High Very High
Lung Injury 17 96.24 Very High Very High Very High
Aging 64 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have shown that morphine enhances accumulation of collagen in cultured fibroblasts.
Positive_regulation (enhances) of Positive_regulation (accumulation) of collagen in fibroblasts associated with morphine
1) Confidence 0.46 Published 2010 Journal J Anesth Section Abstract Doc Link 20127122 Disease Relevance 0.36 Pain Relevance 0.55
On the other hand, 17 beta-estradiol increases the accumulation of collagen in the prostate [67].
Positive_regulation (increases) of Positive_regulation (accumulation) of collagen
2) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.69 Pain Relevance 0.10
The frequency of collagen -specific T cells in the spleen and the Th1/Th2 effector lineage of these cells were determined using cytokine ELISPOT by measuring collagen-induced IFN-?
Positive_regulation (measuring) of Positive_regulation (induced) of collagen in spleen associated with cytokine
3) Confidence 0.07 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0.08 Pain Relevance 0.09
production in their lungs in a manner that precedes the inflammatory response and the accumulation of lung collagen [3].
Positive_regulation (precedes) of Positive_regulation (accumulation) of collagen in lung associated with inflammatory response
4) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 1.10 Pain Relevance 0.26
type II receptor, Wang et al [40] found that pulmonary fibrosis, including excess collagen accumulation, was greatly reduced in hamsters after bleomycin administration.
Positive_regulation (excess) of Positive_regulation (accumulation) of collagen associated with fibrosis and pulmonary fibrosis
5) Confidence 0.02 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.81 Pain Relevance 0.29
Development of G6PI arthritis is associated with a strong antibody response to G6PI and a weak response to type II collagen
Positive_regulation (response) of Positive_regulation (response) of collagen associated with arthritis
6) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 1.96 Pain Relevance 0.36
For example, collagen accumulation in osteoblastic cells was enhanced by vitamin K2 treatment and tsukushi, a small leucine-rich proteoglycan, contributes to this process, as demonstrated by gain- and loss-of-function analyses.
Positive_regulation (contributes) of Positive_regulation (accumulation) of collagen associated with osteoporosis
7) Confidence 0.01 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.73 Pain Relevance 0
For example, collagen accumulation in osteoblastic cells was enhanced by vitamin K2 treatment and tsukushi, a small leucine-rich proteoglycan, contributes to this process, as demonstrated by gain- and loss-of-function analyses.
Positive_regulation (enhanced) of Positive_regulation (accumulation) of collagen associated with osteoporosis
8) Confidence 0.01 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.67 Pain Relevance 0

General Comments

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