INT166134

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 5.69
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cxcl12, Cxcr4) endosome (Cxcr4) extracellular space (Cxcl12)
cytoplasmic membrane-bounded vesicle (Cxcr4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
bladder 2
dorsal root ganglia 1
Cxcl12 (Rattus norvegicus)
Cxcr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
neuralgia 3 99.46 Very High Very High Very High
Inflammation 233 99.28 Very High Very High Very High
chemokine 236 98.84 Very High Very High Very High
cytokine 46 98.68 Very High Very High Very High
Sciatic nerve 17 98.04 Very High Very High Very High
Neuropathic pain 19 96.64 Very High Very High Very High
anesthesia 7 94.52 High High
Stimulus evoked pain 18 91.84 High High
Eae 11 89.72 High High
dorsal root ganglion 28 81.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 243 99.28 Very High Very High Very High
Injury 63 97.72 Very High Very High Very High
Nervous System Injury 29 97.72 Very High Very High Very High
Neuropathic Pain 29 96.64 Very High Very High Very High
Bladder Cancer 21 94.08 High High
Cystitis 119 93.96 High High
Colon Cancer 7 93.76 High High
Inflammatory Bowel Disease 7 92.48 High High
Pain 47 91.84 High High
Hypersensitivity 18 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Until recently, CXCR4 was considered to bind exclusively to SDF-1 [19].
SDF-1 Binding (bind) of CXCR4
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.33 Pain Relevance 0.30
Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic nerve injury as a model of neuropathic pain.
SDF1 Binding (receptor) of CXCR4 in dorsal root ganglia associated with neuralgia, nervous system injury, neuropathic pain and sciatic nerve
2) Confidence 0.40 Published 2010 Journal Histochem. Cell Biol. Section Title Doc Link 20127490 Disease Relevance 0.90 Pain Relevance 0.91
The results from the present study indicate that MIF, by associating with CXCR4 receptors in the bladder (presumably urothelial in origin), may be competing with SDF-1 at CXCR4 receptors to participate in epithelial repair following injury.
SDF-1 Binding (competing) of CXCR4 in bladder associated with injury
3) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 1.18 Pain Relevance 0.62
ELISA determined MIF and stromal derived factor-1 (SDF-1; cognate ligand for CXCR4) levels.
SDF-1 Spec (determined) Binding (ligand) of CXCR4
4) Confidence 0.38 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2588654 Disease Relevance 0.41 Pain Relevance 0.21
Therefore, we examined: 1) location of cytokine receptor CXCR4 in the rat bladder; 2) baseline bladder levels of SDF-1 (cognate ligand for CXCR4) and changes in response to a chemically-induced (cyclophosphamide; CYP) model of bladder inflammation; 3) CXCR4 expression changes after CYP-induced cystitis and 4) association between CXCR4 and MIF in the bladder before and after CYP-induced cystitis.
SDF-1 Binding (ligand) of CXCR4 in bladder associated with inflammation, cystitis and cytokine
5) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.69 Pain Relevance 0.24
Although chemokines typically display a high degree of receptor promiscuity, CXCR4 was (until recently) thought to bind only to SDF-1 [19].
SDF-1 Binding (bind) of CXCR4 associated with chemokine
6) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.50 Pain Relevance 0.26
SDF-1 is the unique ligand for the CXCR4 receptor [31,32].
SDF-1 Binding (ligand) of CXCR4 receptor
7) Confidence 0.34 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.69 Pain Relevance 0.07
MIF, however, competed with the recognized ligand for CXCR4 (SDF-1/CXCL12) for binding to CXCR4 [18].
CXCL12 Binding (binding) of CXCR4
8) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.49 Pain Relevance 0.28
MIF, however, competed with the recognized ligand for CXCR4 (SDF-1/CXCL12) for binding to CXCR4 [18].
SDF-1 Binding (binding) of CXCR4
9) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2588654 Disease Relevance 0.49 Pain Relevance 0.28

General Comments

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