INT166147

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.20
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl25)
Anatomy Link Frequency
monocytes 1
peritoneal macrophages 1
Ccl25 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 208 99.78 Very High Very High Very High
chemokine 61 88.08 High High
cytokine 10 57.76 Quite High
palliative 1 46.04 Quite Low
Inflammation 20 5.00 Very Low Very Low Very Low
Crohn's disease 8 5.00 Very Low Very Low Very Low
Arthritis 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 246 99.78 Very High Very High Very High
Apoptosis 2 98.00 Very High Very High Very High
Reprotox - General 1 9 95.80 Very High Very High Very High
Cancer 8 86.56 High High
Disease 32 24.32 Low Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Acute Monocytic Leukemia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, targeting CCR9-CCL25 axis with cytotoxic agents may provide better therapeutic outcomes than using cytotoxic agents alone.
Positive_regulation (targeting) of CCL25
1) Confidence 0.49 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 20127861 Disease Relevance 0.53 Pain Relevance 0.03
CCL25 was originally defined as being chemotactic for activated, but not resting, human monocytic THP-1 cells, and activated mouse peritoneal macrophages [23].
Positive_regulation (activated) of CCL25 in peritoneal macrophages
2) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.48 Pain Relevance 0.28
On RA monocytes CCL25 (0 to 500 ng/ml) gave a significant increase in CD36 expression on RA monocytes (P < 0.001) (Figure 5c).
Positive_regulation (increase) of CCL25 in monocytes associated with rheumatoid arthritis
3) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.20 Pain Relevance 0.24

General Comments

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