INT166150

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.42
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl25)
Ccl25 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 32 99.68 Very High Very High Very High
palliative 2 86.16 High High
Inflammation 10 83.48 Quite High
rheumatoid arthritis 104 67.52 Quite High
cytokine 5 34.24 Quite Low
Etanercept 1 29.84 Quite Low
methotrexate 2 28.88 Quite Low
Leflunomide 1 27.76 Quite Low
Pain 1 13.64 Low Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 15 99.40 Very High Very High Very High
Cancer 7 94.32 High High
Leukemia 1 89.12 High High
Inflammatory Bowel Disease 1 84.04 Quite High
Disease 16 82.00 Quite High
INFLAMMATION 8 81.68 Quite High
Apoptosis 4 77.52 Quite High
Rheumatoid Arthritis 123 67.52 Quite High
Adhesions 3 40.64 Quite Low
Pain 1 13.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide.
CCL25 Binding (interaction) of associated with reprotox - general 1
1) Confidence 0.47 Published 2010 Journal Int. J. Cancer Section Title Doc Link 20127861 Disease Relevance 0.70 Pain Relevance 0.12
Furthermore, the cytotoxic effect of etoposide was significantly inhibited in the presence of CCL25, and this inhibitory effect of CCL25 was abrogated when CCR9-CCL25 interaction was blocked using anti-CCR9 monoclonal antibodies.
CCL25 Binding (interaction) of
2) Confidence 0.35 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 20127861 Disease Relevance 0.77 Pain Relevance 0.10
Contrary to many other chemokine receptors CCR9 binds only one known ligand, CCL25/TECK.
CCL25 Binding (binds) of associated with chemokine
3) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.96 Pain Relevance 0.40

General Comments

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