INT166157

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Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 2.14
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr9, Pik3r1) plasma membrane (Ccr9, Pik3r1) intracellular (Pik3r1)
protein complex (Pik3r1) cytoplasm (Pik3r1) signal transducer activity (Ccr9)
Ccr9 (Mus musculus)
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 3 100.00 Very High Very High Very High
palliative 3 88.16 High High
Disease Link Frequency Relevance Heat
Reprotox - General 1 21 98.40 Very High Very High Very High
Apoptosis 6 96.76 Very High Very High Very High
Cancer 6 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we show that CC chemokine receptor-9 (CCR9) and its natural ligand CCL25 interaction upregulates antiapoptotic proteins (i.e., PI3K, AKT, ERK1/2 and GSK-3beta) and downregulate activation of caspase-3 in PCa cells.
CCR9 Positive_regulation (upregulates) of PI3K associated with chemokine and reprotox - general 1
1) Confidence 0.55 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 20127861 Disease Relevance 0.73 Pain Relevance 0.14
In this study, we show that CC chemokine receptor-9 (CCR9) and its natural ligand CCL25 interaction upregulates antiapoptotic proteins (i.e., PI3K, AKT, ERK1/2 and GSK-3beta) and downregulate activation of caspase-3 in PCa cells.
chemokine receptor-9 Positive_regulation (upregulates) of PI3K associated with chemokine and reprotox - general 1
2) Confidence 0.48 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 20127861 Disease Relevance 0.74 Pain Relevance 0.14
CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide.
CCR9 Positive_regulation (mediates) of PI3K associated with reprotox - general 1
3) Confidence 0.40 Published 2010 Journal Int. J. Cancer Section Title Doc Link 20127861 Disease Relevance 0.67 Pain Relevance 0.12

General Comments

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