INT166160

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 7
Disease Relevance 5.06
Pain Relevance 0.84

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extracellular space (Ccl25) signal transduction (Ccr9) plasma membrane (Ccr9)
signal transducer activity (Ccr9)
Ccr9 (Mus musculus)
Ccl25 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 7 100.00 Very High Very High Very High
palliative 7 88.16 High High
Disease Link Frequency Relevance Heat
Reprotox - General 1 49 99.50 Very High Very High Very High
Apoptosis 14 96.76 Very High Very High Very High
Cancer 14 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the cytotoxic effect of etoposide was significantly inhibited in the presence of CCL25, and this inhibitory effect of CCL25 was abrogated when CCR9-CCL25 interaction was blocked using anti-CCR9 monoclonal antibodies.
CCR9 Binding (interaction) of CCL25
1) Confidence 0.40 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 20127861 Disease Relevance 0.77 Pain Relevance 0.11
In this study, we show that CC chemokine receptor-9 (CCR9) and its natural ligand CCL25 interaction upregulates antiapoptotic proteins (i.e., PI3K, AKT, ERK1/2 and GSK-3beta) and downregulate activation of caspase-3 in PCa cells.
CCR9 Binding (interaction) of CCL25 associated with chemokine and reprotox - general 1
2) Confidence 0.40 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 20127861 Disease Relevance 0.68 Pain Relevance 0.14
Furthermore, the cytotoxic effect of etoposide was significantly inhibited in the presence of CCL25, and this inhibitory effect of CCL25 was abrogated when CCR9-CCL25 interaction was blocked using anti-CCR9 monoclonal antibodies.
CCR9 Binding (interaction) of CCL25
3) Confidence 0.38 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 20127861 Disease Relevance 0.77 Pain Relevance 0.10
CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide.
CCR9 Binding (interaction) of CCL25 associated with reprotox - general 1
4) Confidence 0.38 Published 2010 Journal Int. J. Cancer Section Title Doc Link 20127861 Disease Relevance 0.70 Pain Relevance 0.12
Furthermore, the cytotoxic effect of etoposide was significantly inhibited in the presence of CCL25, and this inhibitory effect of CCL25 was abrogated when CCR9-CCL25 interaction was blocked using anti-CCR9 monoclonal antibodies.
CCR9 Binding (interaction) of CCL25
5) Confidence 0.38 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 20127861 Disease Relevance 0.77 Pain Relevance 0.10
CCR9 mediates PI3K/AKT-dependent antiapoptotic signals in prostate cancer cells and inhibition of CCR9-CCL25 interaction enhances the cytotoxic effects of etoposide.
CCR9 Binding (interaction) of CCL25 associated with reprotox - general 1
6) Confidence 0.38 Published 2010 Journal Int. J. Cancer Section Title Doc Link 20127861 Disease Relevance 0.70 Pain Relevance 0.12
In this study, we show that CC chemokine receptor-9 (CCR9) and its natural ligand CCL25 interaction upregulates antiapoptotic proteins (i.e., PI3K, AKT, ERK1/2 and GSK-3beta) and downregulate activation of caspase-3 in PCa cells.
chemokine receptor-9 Binding (interaction) of CCL25 associated with chemokine and reprotox - general 1
7) Confidence 0.35 Published 2010 Journal Int. J. Cancer Section Abstract Doc Link 20127861 Disease Relevance 0.68 Pain Relevance 0.14

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