INT166171

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.98
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HRAS) signal transduction (HRAS) Golgi apparatus (HRAS)
plasma membrane (HRAS) nucleus (HRAS) GTPase activity (HRAS)
Anatomy Link Frequency
NHEK 2
HRAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 27 99.70 Very High Very High Very High
Pain 8 98.92 Very High Very High Very High
cINOD 1 98.30 Very High Very High Very High
Osteoarthritis 17 90.88 High High
Angina 1 87.28 High High
Kinase C 15 73.04 Quite High
cytokine 10 55.96 Quite High
Analgesic 1 50.96 Quite High
rheumatoid arthritis 3 47.36 Quite Low
fibrosis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 31 99.70 Very High Very High Very High
Pancreatic Ductal Carcinoma 34 99.52 Very High Very High Very High
Hyperplasia 36 98.96 Very High Very High Very High
Pain 8 98.92 Very High Very High Very High
Cancer 38 93.08 High High
Toxicity 7 92.64 High High
Osteoarthritis 21 90.88 High High
Malignant Neoplastic Disease 1 88.96 High High
Cv General 3 Under Development 1 87.28 High High
Pressure And Volume Under Development 2 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HA production in normal human epidermal keratinocytes (NHEK) was measured after 48 hours incubation with PR and its hydrolysate, respectively.
Negative_regulation (measured) of Gene_expression (production) of HA in NHEK
1) Confidence 0.07 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20128051 Disease Relevance 0.25 Pain Relevance 0.09
A 20 mer PS-ODN, ISIS 2503 (ISIS Pharmaceuticals), targeted to the translation initiation region of H-ras mRNA selectively reduced the expression of H-ras protein in vitro [84].
Negative_regulation (reduced) of Gene_expression (expression) of H-ras protein
2) Confidence 0.04 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 0.82 Pain Relevance 0.04
Namely, the IC adjacent to the atypical MGH (PanIN-1B), which is sometimes proliferative cell, had the mucin phenotypic expression and high frequency of K-ras mutation as well as PDC.
Negative_regulation (had) of Gene_expression (expression) of K-ras mutation associated with pancreatic ductal carcinoma and hyperplasia
3) Confidence 0.03 Published 2005 Journal J Carcinog Section Body Doc Link PMC1185555 Disease Relevance 1.72 Pain Relevance 0
HA is synthesized by hyaluronic acid synthases (HAS) which covalently link the monomeric building blocks glucuronic acid and N-Acetyl-glucosamine (GlcN-Ac) in an alternating fashion.
Negative_regulation (blocks) of Gene_expression (synthesized) of HA
4) Confidence 0.02 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2553787 Disease Relevance 0.90 Pain Relevance 0.74
It has been suggested that the nonsteroidal anti-inflammatory drugs, such as indomethacin, may exert a portion of their anti-inflammatory properties by inhibiting hyaluronidase and, hence, the generation of small HA fragments [56].
Negative_regulation (inhibiting) of Gene_expression (generation) of HA associated with inflammation and cinod
5) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175024 Disease Relevance 0.29 Pain Relevance 0.25

General Comments

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