INT166177

Context Info Confidence 0.48 First Reported 2008 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 8 Disease Relevance 4.64 Pain Relevance 0.26

cell differentiation (H1fnt) chromosome (H1fnt) nucleus (H1fnt) DNA binding (H1fnt)

Anatomy Link Frequency respiratory 1 H1fnt (Mus musculus)

Pain Link Frequency Relevance Heat headache 16 91.28 Analgesic 16 45.32 Pain 1 25.00 cytokine 8 5.00 depression 8 5.00 anesthesia 3 5.00 addiction 2 5.00

Disease Link Frequency Relevance Heat Influenza Virus Infection 248 100.00 Sprains And Strains 124 100.00 Infection 94 100.00 Pox Virus Infection 52 100.00 Respiratory Syncytial Virus 50 99.80 Lower Respiratory Tract Infection 4 96.36 Headache 16 91.28 Immunization 22 79.88 Pneumonia 5 70.08 Syndrome 8 61.40

Sentences Mentioned In

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If a significant number of cases appear in older persons, the recommendations for H1N1 vaccination may need to be changed to include the elderly.

Gene_expression (vaccination) of H1N1

1) Confidence 0.48 Published 2010 Journal J Am Med Dir Assoc Section Abstract Doc Link 20129209 Disease Relevance 0.17 Pain Relevance 0

For children, the rate differences for all solicited symptoms were not statistically significant between H1N1 LAIV and placebo recipients.

Neg (not) Gene_expression (significant) of H1N1 LAIV

2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966412 Disease Relevance 0.31 Pain Relevance 0.26

The seroresponse rates observed in placebo recipients in both studies is likely attributable to 2009 H1N1 infections occurring in the U.S. during the period in which these studies were conducted.

Gene_expression (infections) of H1N1 associated with infection

3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966412 Disease Relevance 0.43 Pain Relevance 0

In response to the 2009 H1N1 influenza pandemic, MedImmune (Gaithersburg, MD) developed a live attenuated intranasal H1N1 vaccine based on the Ann Arbor 6?

Gene_expression (vaccine) of H1N1 associated with influenza virus infection

4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966412 Disease Relevance 0.36 Pain Relevance 0

The 2009 H1N1 LAIV was produced by MedImmune and was derived by genetic reassortment of the hemagglutinin and neuraminidase genes from the wild-type A/California/7/2009 virus and the remaining 6 gene segments from an attenuated master donor virus as previously described [1], [2], [18].

Gene_expression (produced) of H1N1 LAIV

5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966412 Disease Relevance 0.10 Pain Relevance 0

The purpose of this study was to evaluate the immune response and the protective potential of MVA-based influenza vaccines expressing the protective antigens hemagglutinin and neuraminidase of the novel H1N1 strain.

Gene_expression (expressing) of H1N1 associated with influenza virus infection and sprains and strains

6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.41 Pain Relevance 0

In the current study, experimental vaccinia-based pandemic H1N1 influenza live vaccines expressing either the hemaglutinin or the neuraminidase of the novel swine H1N1 influenza strain were analysed.

Gene_expression (expressing) of H1N1 associated with pox virus infection, influenza virus infection and sprains and strains

7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 1.15 Pain Relevance 0

We used two respiratory viruses, RSV (strain A2) and influenza virus A/Puerto Rico/8/34 (H1N1), which were administered IN, and a non-respiratory virus, a recombinant Western Reserve (WR) strain of vaccinia virus (VV) expressing the RSV M2-1 protein (VV-M2), which was administered either by the IN or ID route.

Gene_expression (expressing) of H1N1 in respiratory associated with pox virus infection, influenza virus infection, sprains and strains and respiratory syncytial virus

8) Confidence 0.01 Published 2008 Journal Virol J Section Body Doc Link PMC2561024 Disease Relevance 1.70 Pain Relevance 0

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