INT166184

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.27
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF2AK2) intracellular (EIF2AK2) translation (EIF2AK2)
Anatomy Link Frequency
reticulum 1
EIF2AK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 95.12 Very High Very High Very High
Inflammation 1 86.00 High High
Disease Link Frequency Relevance Heat
Stress 7 99.12 Very High Very High Very High
Cancer 3 97.16 Very High Very High Very High
Apoptosis 4 89.84 High High
INFLAMMATION 1 86.00 High High
Colon Cancer 2 85.20 High High
Intestinal Cancer 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac sulfide, the active sulindac metabolite, was shown to trigger the ISRs via eIF2alpha kinase such as RNA-dependent protein kinase-related endoplasmic reticulum kinase (PERK) and RNA-dependent protein kinase (PKR).
Positive_regulation (trigger) of RNA-dependent protein kinase in reticulum
1) Confidence 0.24 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20130018 Disease Relevance 1.27 Pain Relevance 0.47

General Comments

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