INT166203

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 62
Total Number 65
Disease Relevance 75.94
Pain Relevance 31.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tail 3
CII 3
joints 3
T cells 3
knee joints 1
Cia1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 5155 100.00 Very High Very High Very High
rheumatoid arthritis 2135 100.00 Very High Very High Very High
Inflammation 1339 99.84 Very High Very High Very High
dexamethasone 30 99.48 Very High Very High Very High
Etanercept 28 99.44 Very High Very High Very High
fluoxetine 2 99.06 Very High Very High Very High
cytokine 925 99.04 Very High Very High Very High
Acupuncture 114 98.86 Very High Very High Very High
sSRI 3 98.82 Very High Very High Very High
addiction 11 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 5291 100.00 Very High Very High Very High
Rheumatoid Arthritis 2166 100.00 Very High Very High Very High
Disease 1256 100.00 Very High Very High Very High
Experimental Arthritis 209 100.00 Very High Very High Very High
INFLAMMATION 1437 99.84 Very High Very High Very High
Immunization 379 99.84 Very High Very High Very High
Arthropathy 97 99.84 Very High Very High Very High
Targeted Disruption 156 99.54 Very High Very High Very High
Sprains And Strains 138 99.32 Very High Very High Very High
Autoimmune Disease 328 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collagen-induced arthritis (CIA) in susceptible strains of mice has become a valuable animal model in RA research because of its simplicity, rapid disease onset, and reproducibility.
Positive_regulation (induced) of CIA associated with rheumatoid arthritis, disease, sprains and strains and arthritis
1) Confidence 0.43 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246242 Disease Relevance 1.63 Pain Relevance 0.51
CIA was induced in 45 female DBA/1LacJ mice (8 to 10 weeks old) by immunization with lyophilized bovine articular type II collagen.
Positive_regulation (induced) of CIA in articular associated with immunization and arthritis
2) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2246242 Disease Relevance 0.79 Pain Relevance 0.39
We demonstrated that postural and kinematic gait disturbances corresponded to clinical scores with increasing severity of the CIA.
Positive_regulation (increasing) of CIA associated with arthritis
3) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246242 Disease Relevance 0.70 Pain Relevance 0.31
Arthritis produced by passive transfer of CII mAbs resembles actively induced CIA but in an acute form (Figure 1) with a much more rapid onset (24 to 48 hours).
Positive_regulation (induced) of CIA in CII associated with arthritis
4) Confidence 0.27 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.25 Pain Relevance 0.48
Although ACPAs were not detectable in earlier studies with collagen-induced arthritis (CIA) [20,21], a recent study reported the presence of these antibodies during the early phase of CIA [22].
Positive_regulation (induced) of CIA associated with arthritis
5) Confidence 0.25 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 0.95 Pain Relevance 0.44
Induction and analysis of CIA
Positive_regulation (Induction) of CIA associated with arthritis
6) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 0.98 Pain Relevance 0.31
Immunization of rodents and primates with CII in adjuvant induced an autoimmune arthritis, the so called CIA that, in many ways, resembles RA [29-32].
Positive_regulation (induced) of CIA in CII associated with immunization, rheumatoid arthritis and arthritis
7) Confidence 0.23 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 1.94 Pain Relevance 0.55
Although our results suggest a potential role of Gr-1+ cells on the induction of autoimmunity, depletion of Gr-1+ cells does not eliminate the induction of CIA by antigen+adjuvant (Figure 4B).
Positive_regulation (induction) of CIA associated with autoimmune disease and arthritis
8) Confidence 0.21 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.66 Pain Relevance 0.84
CIA induction and scoring for CIA development
Positive_regulation (induction) of CIA associated with arthritis
9) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.69 Pain Relevance 0.19
E/P-selectin mutant mice were kept on antibiotics (neomycin sulfate, tetracycline, and trimethoprim) until 2 weeks before the induction of CIA in order to inhibit the development of mucocutaneous infections, which commonly occur in these mice [15].
Positive_regulation (induction) of CIA associated with infection and arthritis
10) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.82 Pain Relevance 0.34
Therefore, our data further support the concept that sH4 functions as a decoy molecule to block endogenous B7-H4, leading to increased autoimmune responses and exacerbated CIA.


Positive_regulation (increased) of CIA associated with arthritis
11) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.15 Pain Relevance 0.34
In contrast, introduction of the plasmid encoding B7-H4Ig could prevent disease induction of CIA.
Positive_regulation (induction) of CIA associated with disease and arthritis
12) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.65 Pain Relevance 0.55
Semi-therapeutic treatment of CIA
Positive_regulation (treatment) of CIA associated with arthritis
13) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 1.23 Pain Relevance 0.27
However, CIA is an experimentally induced arthritis that is strongly mediated by inflammation.
Positive_regulation (mediated) of CIA associated with inflammation and arthritis
14) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 1.14 Pain Relevance 0.70
As expected, semi-therapeutic treatment of mice with dexamethasone completely abolished the induction of CIA.
Positive_regulation (induction) of CIA associated with dexamethasone and arthritis
15) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945063 Disease Relevance 0.77 Pain Relevance 0.67
The novel finding of our study is that IDO activity is upregulated in the acute phase of CIA reflected by the increased K/T ratio in the serum.
Positive_regulation (upregulated) of CIA associated with arthritis
16) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.33 Pain Relevance 0.46
CIA was induced in 8- to 10-wk-old male DBA/1j mice by intradermal tail base injection of 0.2 mg chicken collagen (Sigma-Aldrich) in 0.05 M acetic acid, supplemented with 4.0 mg/ml Mycobacterium tuberculosis (DIFCO, Detroit, MI) emulsified in complete Freund adjuvant.
Positive_regulation (induced) of CIA in tail associated with mycobacterial infection, freund adjuvant and arthritis
17) Confidence 0.14 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.79 Pain Relevance 0.18
Induction of CIA
Positive_regulation (Induction) of CIA associated with arthritis
18) Confidence 0.14 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.72 Pain Relevance 0.17
In contrast to the treatment in the induction phase, depletion of Gr-1+ cells in the effector phase had only a marginal effect in B7-H4VC plasmid-induced CIA exacerbation (Figure S9).
Positive_regulation (induced) of CIA associated with arthritis
19) Confidence 0.13 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 0.93 Pain Relevance 0.46
Increased CIA clinical score induced by sH4 was eliminated by this treatment (B7-H4VC+Ctl IgG group versus B7-H4VC+anti-Gr-1 mAb group) (Figure 4B).
Positive_regulation (Increased) of CIA associated with arthritis
20) Confidence 0.13 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2760136 Disease Relevance 1.10 Pain Relevance 0.42

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