INT166227

Context Info Confidence 0.05 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.26 Pain Relevance 1.03

HCL1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 10 99.62 antagonist 1 98.12 antidepressant 1 87.36 Inflammation 3 67.48 Pain 1 65.00 nud 8 25.12 Serotonin 1 5.00 Calcium channel 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 5 96.08 Ulcers 6 94.36 Stress 5 93.76 Anxiety Disorder 1 85.84 Hemorrhage 2 80.36 Toxicity 2 75.00 Disease 8 74.76 Neurological Disease 1 73.72 Gastroesophageal Reflux Disease 49 72.80 Cancer 1 72.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, Kato et al. [7] demonstrated the inhibitory action of melatonin on secretion of HCL and pepsin.

Negative_regulation (action) of Localization (secretion) of HCL

1) Confidence 0.05 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.62 Pain Relevance 0.14

We also discuss current alternative approaches being taken to mitigate the GI side-effects of NSAIDs, including developing combination drugs where NSAIDs are packaged with inhibitors of HCl secretion such as proton pump inhibitors or H2-receptor antagonists.

Negative_regulation (inhibitors) of Localization (secretion) of HCl associated with antagonist and cinod

2) Confidence 0.03 Published 2009 Journal Drugs Today Section Abstract Doc Link 20135022 Disease Relevance 0.64 Pain Relevance 0.89

General Comments

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