INT16624

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Context Info
Confidence 0.79
First Reported 1987
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 38
Total Number 42
Disease Relevance 8.46
Pain Relevance 17.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
neurons 5
dendrites 3
plasma 1
cleavage 1
supraoptic nucleus 1
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 485 100.00 Very High Very High Very High
Glutamate 372 100.00 Very High Very High Very High
Pain 56 100.00 Very High Very High Very High
Glutamate receptor 50 100.00 Very High Very High Very High
Neurotransmitter 29 100.00 Very High Very High Very High
excitatory amino acid 3 100.00 Very High Very High Very High
noradrenaline 9 99.98 Very High Very High Very High
antagonist 196 99.96 Very High Very High Very High
agonist 32 99.92 Very High Very High Very High
Kappa opioid receptor 20 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 66 99.16 Very High Very High Very High
Neuropathic Pain 124 98.16 Very High Very High Very High
Apoptosis 21 96.84 Very High Very High Very High
Peripheral Arterial Disease 2 96.40 Very High Very High Very High
Pain 71 95.36 Very High Very High Very High
Colitis 51 95.36 Very High Very High Very High
INFLAMMATION 247 95.28 Very High Very High Very High
Stupor 20 93.44 High High
Ganglion Cysts 44 92.80 High High
Infection 102 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localization of AMPA receptor subunits (GluR1-4), a KA receptor subunit (GluR5) and NMDA receptor subunits (NR1 and NRgbs; the glutamate binding subunits of an NMDA receptor complex) was investigated using immunohistochemistry and in situ hybridization histochemistry in the rat dorsal root ganglion.
Spec (investigated) Localization (localization) of NR1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, glutamate and nmda receptor
1) Confidence 0.79 Published 1993 Journal Neuroreport Section Abstract Doc Link 8219025 Disease Relevance 0.09 Pain Relevance 0.26
In addition, the study indicated that ER retention signals in the alternatively spliced C-terminal domain of the NR1 subunit control release of NR1 from ER and is regulated by PKC phosphorylation [43].
Localization (release) of NR1
2) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.43 Pain Relevance 0.27
Sensitization of glutamate release and N-methyl-D-aspartate receptor response by transient dopamine pretreatment in prefrontal cortex of rats.
Localization (Sensitization) of N-methyl-D-aspartate receptor in prefrontal associated with pain, dopamine, glutamate and nmda receptor
3) Confidence 0.75 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 11755249 Disease Relevance 0.07 Pain Relevance 0.49
Rostrocaudal variation in targeting of N-methyl-D-aspartate and mu-opioid receptors in the rat medial nucleus of the solitary tract.
Localization (targeting) of N-methyl-D-aspartate in medial associated with mu opioid receptor
4) Confidence 0.74 Published 2000 Journal J. Comp. Neurol. Section Title Doc Link 10813795 Disease Relevance 0 Pain Relevance 0.41
Furthermore, it is showed that IL-1R and NR1 are co-localized in spinal neurons [48].
Localization (localized) of NR1 in spinal
5) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.44 Pain Relevance 0.85
In addition, the colocalization of MOR and NMDAR1 in certain axon terminals in the Acb suggests their dual involvement in the presynaptic release of neurotransmitters in this region.
Localization (colocalization) of NMDAR1 in Acb associated with nucleus accumbens and neurotransmitter
6) Confidence 0.71 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9169542 Disease Relevance 0 Pain Relevance 0.61
In dendrites and spines, MOR-IR was localized mainly along nonsynaptic plasma membranes, whereas NR1-IR was more often associated with asymmetric postsynaptic densities and cytoplasmic organelles.
Localization (localized) of NR1 in spines
7) Confidence 0.69 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10440715 Disease Relevance 0 Pain Relevance 0.36
In addition, the study indicated that ER retention signals in the alternatively spliced C-terminal domain of the NR1 subunit control release of NR1 from ER and is regulated by PKC phosphorylation [43].
Localization (release) of NR1 subunit
8) Confidence 0.68 Published 2006 Journal Mol Pain Section Body Doc Link PMC1402265 Disease Relevance 0.43 Pain Relevance 0.27
Immunofluorescence with an antibody that recognized NR1 and another that recognized NR2A and NR2B showed that NR1 and NR2B colocalized in 90% of DRG neurons, including most A-fibers (identified by the presence of neurofilament 200 kDa).
Localization (colocalized) of NR1 in neurons
9) Confidence 0.68 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11954032 Disease Relevance 0.08 Pain Relevance 0.24
Furthermore, the co-localization of formalin injection-evoked Zif/268 and c-Fos expression and subunit 1 of the NMDA receptor (NR1) was studied in this nucleus.
Localization (localization) of NR1 in nucleus associated with nmda receptor
10) Confidence 0.67 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 14596893 Disease Relevance 0.17 Pain Relevance 0.38
Putative mechanisms for mediating this change include alterations of GABA-ergic systems and/or plasticity related to alterations in N-methyl-D-aspartate receptor activation and nitric oxide release related to afferent hyperactivity induced by neuropathic pain.
Localization (release) of N-methyl-D-aspartate receptor associated with gaba, nmda receptor, neuropathic pain and attention deficit hyperactivity disorder
11) Confidence 0.65 Published 2002 Journal Pain Section Abstract Doc Link 12237215 Disease Relevance 0.27 Pain Relevance 0.69
METHODS AND RESULTS: Immunohistochemical localization of the NR1 subunit showed that NMDA receptors are expressed on the cell bodies and peripheral terminals of primary afferent nerves innervating the colon.
Localization (localization) of NR1 in colon
12) Confidence 0.65 Published 2001 Journal Gastroenterology Section Body Doc Link 11375955 Disease Relevance 0.10 Pain Relevance 0
Serine phosphorylation of the NR1 subunit with C1 cassette appears at 14 days after TNBS injection.
Localization (cassette) of NR1
13) Confidence 0.63 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16942839 Disease Relevance 0.62 Pain Relevance 0.42
KOR and NR1 also were colocalized within dendrites, and rarely were observed in the same cell bodies.
Localization (observed) of NR1 in dendrites associated with nmda receptor and kappa opioid receptor
14) Confidence 0.62 Published 2002 Journal Brain Res. Section Abstract Doc Link 12137930 Disease Relevance 0 Pain Relevance 0.88
KOR and NR1 also were colocalized within dendrites, and rarely were observed in the same cell bodies.
Localization (colocalized) of NR1 in dendrites associated with nmda receptor and kappa opioid receptor
15) Confidence 0.62 Published 2002 Journal Brain Res. Section Abstract Doc Link 12137930 Disease Relevance 0 Pain Relevance 0.87
In these profiles, MOR labeling was localized mainly to extrasynaptic plasma membranes, whereas NMDAR1-LI was associated with both synaptic and extrasynaptic sites.
Localization (localized) of NMDAR1 in plasma
16) Confidence 0.62 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9169542 Disease Relevance 0 Pain Relevance 0.69
However, the group did not determine whether these NR1 subunits were localized to any specific area of the cord such as the dorsal horn or whether they were distributed throughout the lamina.
Localization (localized) of NR1 in dorsal horn associated with dorsal horn
17) Confidence 0.61 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208948 Disease Relevance 0.55 Pain Relevance 0.44
In vulnerable neurons, excitotoxic insult induces a sustained positive feedback loop between NMDA-R-dependent current and depolarization-mediated glutamate release, which drives Ca++ elevation and delayed excitotoxicity.
Localization (release) of NMDA-R in neurons associated with glutamate
18) Confidence 0.59 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3002330 Disease Relevance 0.22 Pain Relevance 0.38
Furthermore, whole-cell patch clamp recordings of miniature excitatory postsynaptic currents in cultured rat hippocampal neurons showed that patients' antibodies specifically decreased synaptic NMDA-R-mediated currents.
Localization (decreased) of NMDA-R in neurons
19) Confidence 0.55 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC3002330 Disease Relevance 0.47 Pain Relevance 0.25
Double immunofluorescence studies indicated that NR1 is colocalized with mGluR5 in dorsal horn neurons. mGluR5 also coimmunoprecipitates with NR2B.
Localization (colocalized) of NR1 in neurons associated with dorsal horn neuron
20) Confidence 0.55 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15483135 Disease Relevance 0.55 Pain Relevance 1.13

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