INT16626

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Context Info
Confidence 0.30
First Reported 1991
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 2.41
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Adrb2) signal transduction (Adrb2) plasma membrane (Adrb2)
nucleus (Adrb2) cytoplasm (Adrb2) signal transducer activity (Adrb2)
Anatomy Link Frequency
adipocyte 2
myotubes 1
body 1
Adrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1 99.92 Very High Very High Very High
adenocard 3 99.12 Very High Very High Very High
Somatostatin 1 98.56 Very High Very High Very High
agonist 30 98.36 Very High Very High Very High
noradrenaline 2 98.36 Very High Very High Very High
Morphine 4 98.28 Very High Very High Very High
antagonist 5 97.52 Very High Very High Very High
Kappa opioid receptor 5 91.44 High High
Clonidine 6 89.76 High High
opioid receptor 10 88.12 High High
Disease Link Frequency Relevance Heat
Hyperplasia 2 99.46 Very High Very High Very High
Obesity 19 98.84 Very High Very High Very High
Asthma 3 98.44 Very High Very High Very High
Body Weight 3 97.20 Very High Very High Very High
Polycystic Ovary Syndrome 6 83.80 Quite High
Weight Loss 3 80.20 Quite High
Hypokalemia 2 75.00 Quite High
Bordatella Infection 1 46.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of beta-adrenoceptor activation on [Ca2+]i regulation in murine skeletal myotubes.
Positive_regulation (activation) of beta-adrenoceptor in myotubes
1) Confidence 0.30 Published 1999 Journal Am. J. Physiol. Section Title Doc Link 10329950 Disease Relevance 0 Pain Relevance 0.12
Part of the effect could be attributed to beta-adrenoceptor activation, as it was mimicked by the rise in cAMP and inhibited by the antagonist propranolol as well as the protein kinase A inhibitor adenosine 3',5'-cyclic monophosphorothioate Rp-isomer. alpha1-Adrenoceptors were also involved, since the antagonists phentolamine and prazosin completely abolished the effects of adrenaline.
Positive_regulation (activation) of beta-adrenoceptor associated with adenocard and antagonist
2) Confidence 0.23 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14727006 Disease Relevance 0 Pain Relevance 0.21
Thus, glucocorticoids selectively increase beta 2-adrenoceptor density and function in patients with asthma, studied by using subcutaneous fat cells as an experimental model.
Positive_regulation (increase) of 2-adrenoceptor in fat cells associated with asthma and obesity
3) Confidence 0.07 Published 1993 Journal Clin. Sci. Section Abstract Doc Link 8403793 Disease Relevance 0.35 Pain Relevance 0.22
The ability of propranolol but not atenolol to block this change suggests that the acute decrease in K+ levels was due to beta 2-adrenergic receptor stimulation.
Positive_regulation (due) of beta 2-adrenergic
4) Confidence 0.03 Published 1991 Journal Anesth. Analg. Section Abstract Doc Link 1845926 Disease Relevance 0.13 Pain Relevance 0.18
But chronic morphine activation of the delta-OR inhibits cellular proliferation, while chronic procaterol activation of the beta2-AR stimulates it.
Positive_regulation (activation) of beta2-AR associated with hyperplasia and morphine
5) Confidence 0.01 Published 1999 Journal Cell Prolif. Section Abstract Doc Link 10614711 Disease Relevance 0.10 Pain Relevance 0.57
The findings suggest that chronic beta2-AR activation stimulates proliferation by interacting with the ERK signalling cascade independent of a cAMP-mediated pathway.
Positive_regulation (activation) of beta2-AR
6) Confidence 0.01 Published 1999 Journal Cell Prolif. Section Abstract Doc Link 10614711 Disease Relevance 0.09 Pain Relevance 0.54
Polymorphism of the AHSG gene is associated with increased adipocyte beta2-adrenoceptor function.
Positive_regulation (increased) of beta2-adrenoceptor in adipocyte
7) Confidence 0.00 Published 2005 Journal J. Lipid Res. Section Title Doc Link 16024912 Disease Relevance 0.23 Pain Relevance 0.15
This corresponds to an approximately 35-fold increase in beta2-adrenoceptor function.
Positive_regulation (increase) of beta2-adrenoceptor
8) Confidence 0.00 Published 2005 Journal J. Lipid Res. Section Abstract Doc Link 16024912 Disease Relevance 0.27 Pain Relevance 0.21
We conclude that a common variation (Thr230Met) in the AHSG gene is associated with a marked increase in beta2-adrenoceptor sensitivity in subcutaneous fat cells, which may be of importance in body weight regulation.
Positive_regulation (increase) of beta2-adrenoceptor in body associated with body weight and obesity
9) Confidence 0.00 Published 2005 Journal J. Lipid Res. Section Abstract Doc Link 16024912 Disease Relevance 0.41 Pain Relevance 0.22
Furthermore, the stimulation of beta2-adrenergic and VIP receptors also seems to account for its relaxant action.
Positive_regulation (stimulation) of beta2-adrenergic
10) Confidence 0.00 Published 2002 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12079001 Disease Relevance 0 Pain Relevance 0.11
WR caused a 50% reduction of basal lipolysis rate and a 5- to 7-fold increased noradrenaline and terbutaline sensitivity (P < 0.02); the latter could be ascribed to a 2-fold increased beta2-adrenoceptor density (P < 0.02) as determined with radioligand binding.
Positive_regulation (increased) of beta2-adrenoceptor associated with noradrenaline
11) Confidence 0.00 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10372729 Disease Relevance 0.84 Pain Relevance 0.14
Activation of alpha2- and beta2-adrenergic, dopamine D1 and D2, adenosine A1, somatostatin-1 and -2, C5a, formyl peptide, and luteinizing hormone receptors all resulted in stimulation of phospholipase C, with maximal stimulations ranging from 1.5- to almost 17-fold.
Positive_regulation (Activation) of beta2-adrenergic associated with adenocard, dopamine and somatostatin
12) Confidence 0.00 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9572309 Disease Relevance 0 Pain Relevance 0.72

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