INT166274

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.20
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EPHB1) signal transduction (EPHB1) plasma membrane (EPHB1)
cytoplasm (EPHB1)
Anatomy Link Frequency
lymph node 1
endothelial cell 1
stem cells 1
EPHB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 4 99.96 Very High Very High Very High
fluoxetine 5 98.28 Very High Very High Very High
imagery 8 95.08 Very High Very High Very High
Tetrahydrobiopterin 36 93.36 High High
sSRI 2 91.28 High High
antidepressant 3 86.08 High High
Serotonin 3 82.68 Quite High
Desipramine 1 82.64 Quite High
tolerance 6 81.04 Quite High
Acupuncture 4 69.16 Quite High
Disease Link Frequency Relevance Heat
Neuroendocrine Cancer 60 100.00 Very High Very High Very High
Epstein-barr Virus 4 99.60 Very High Very High Very High
Metastasis 30 99.36 Very High Very High Very High
Increased Venous Pressure Under Development 65 98.28 Very High Very High Very High
Diabetes Mellitus 138 97.56 Very High Very High Very High
Hyperlipidemia 12 97.20 Very High Very High Very High
Death 11 96.64 Very High Very High Very High
Hyperglycemia 21 95.84 Very High Very High Very High
Disease 65 94.08 High High
Carcinoma 22 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NET protocol
Gene_expression (protocol) of NET
1) Confidence 0.55 Published 2009 Journal Trials Section Body Doc Link PMC2646715 Disease Relevance 0.15 Pain Relevance 0.03
Sham NET protocol
Gene_expression (protocol) of NET
2) Confidence 0.55 Published 2009 Journal Trials Section Body Doc Link PMC2646715 Disease Relevance 0.09 Pain Relevance 0
The results of this study show that although there is low-level expression of the norepinephrine transporter (NET) in some BL cells, NET is not involved in fluoxetine- or maprotiline-mediated cell death, as neither norepinephrine nor other NET inhibitors prevented this death.
Gene_expression (expression) of NET associated with epstein-barr virus, death and fluoxetine
3) Confidence 0.36 Published 2010 Journal Leuk. Lymphoma Section Abstract Doc Link 20141432 Disease Relevance 0.68 Pain Relevance 0.69
Antarcti.ca used Visual Net technology in Map.Net – (Figures 1 and 12) to provide multilevel (hierarchical/categorical) information maps for browsing over two million Web sites from the Open Directory Project .
Gene_expression (technology) of Net
4) Confidence 0.23 Published 2003 Journal Int J Health Geogr Section Body Doc Link PMC149401 Disease Relevance 0 Pain Relevance 0
Antarcti.ca used Visual Net technology in Map.Net – (Figures 1 and 12) to provide multilevel (hierarchical/categorical) information maps for browsing over two million Web sites from the Open Directory Project .
Gene_expression (technology) of Net
5) Confidence 0.23 Published 2003 Journal Int J Health Geogr Section Body Doc Link PMC149401 Disease Relevance 0 Pain Relevance 0
Global gene expression analysis results showed that Oct4 regulated target genes which could be characterized as differentially regulated genes such as pluripotency markers NANOG, SOX2, and KLF4 and markers of undifferentiated stem cells FOXD1, CDC2, and EPHB1.
Gene_expression (markers) of EPHB1 in stem cells
6) Confidence 0.21 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2747014 Disease Relevance 0.13 Pain Relevance 0.03
Excision of a skin NET and lymph node metastasis was successful in a previous case report [12].
Gene_expression (Excision) of NET in lymph node associated with neuroendocrine cancer and metastasis
7) Confidence 0.12 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 2.07 Pain Relevance 0.03
Since NET usually express somatostatin receptors, scanning with radiolabelled somatostatin analogue (octreotide) is often helpful.
Gene_expression (express) of NET associated with neuroendocrine cancer and somatostatin
8) Confidence 0.12 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 1.92 Pain Relevance 0.28
This review will discuss dysfunction of the eNOS enzyme and its potential to uncouple, resulting in the endothelial cell becoming a net producer of damaging superoxide (O2') instead of the protective eNO (tables 4,5) [6].
Gene_expression (producer) of net in endothelial cell
9) Confidence 0.06 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 0.84 Pain Relevance 0
This attribute allows the eNOS reaction to re-couple and restores the capability of this reaction to be once again a net producer of eNO and restores endothelial dependent vasodilatation in T2DM and hyperlipidemia [38].
Gene_expression (producer) of net associated with diabetes mellitus, hyperlipidemia and increased venous pressure under development
10) Confidence 0.06 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.01 Pain Relevance 0.05
This endogenously produced competitive inhibitor of L-arginine (as well as an endogenous inhibitor of the eNOS reaction) would cause the eNOS reaction to uncouple and become a net producer of superoxide even before the glucose becomes elevated, thus stressing the islet and the intima before hyperglycemia is detected.
Gene_expression (producer) of net associated with hyperglycemia
11) Confidence 0.06 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC151667 Disease Relevance 1.10 Pain Relevance 0.08
Results indicated that net balance was negative in the CHO condition, and positive in the CHO-PRO and CHO-PROL conditions, with the latter attaining the highest values.
Neg (negative) Gene_expression (negative) of net
12) Confidence 0.02 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0.08 Pain Relevance 0
For evaluation of OSBP1, APP, and APP-CTFs expression levels in HEK-APPNFEV, cell monolayers were washed twice with ice-cold PBS and lysed in PBS containing 1% Triton X-100, 1 mM PMSF and Complete protease inhibitor cocktail (Roche, Indianapolis, IN) for 30 min on ice.
Gene_expression (expression) of HEK-APPNFEV
13) Confidence 0.01 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
in the media measured by ELISA in HEK-APPNFEV were also unexpectedly reduced by 24% in HEK-APPNEFV overexpressing OSBP1 (data not shown), suggesting again that OSBP1 overexpression impacts the non-amyloidogenic processing of APP in a more complex manner.


Gene_expression (overexpressing) of HEK-APPNEFV
14) Confidence 0.01 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0

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