INT166276

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.52
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Pfpl) cellular_component (Pfpl) biological_process (Pfpl)
Anatomy Link Frequency
blood 2
Pfpl (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 34 97.60 Very High Very High Very High
COX-2 inhibitor 4 82.52 Quite High
aspirin 20 76.92 Quite High
chemokine 8 66.16 Quite High
cytokine 20 61.24 Quite High
Inflammation 44 50.60 Quite High
Pain 6 48.72 Quite Low
agonist 4 39.48 Quite Low
cva 12 5.00 Very Low Very Low Very Low
Inflammatory marker 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 38 97.60 Very High Very High Very High
Myocardial Infarction 20 97.44 Very High Very High Very High
Adhesions 28 93.32 High High
Diabetes Mellitus 24 89.20 High High
Atherosclerosis 140 74.88 Quite High
Aging 4 72.40 Quite High
Apoptosis 8 68.08 Quite High
Hyperplasia 4 64.56 Quite High
INFLAMMATION 60 60.88 Quite High
Hematologic Neoplasms 12 59.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apheresis was performed, obtaining 50 mL of blood with a high rate of EPCs (CD34(+) and CD133(+) cells were counted).
Positive_regulation (rate) of EPCs in blood
1) Confidence 0.04 Published 2010 Journal Ann Vasc Surg Section Body Doc Link 20142004 Disease Relevance 0 Pain Relevance 0
Early EPCs are positive for several markers, such as CD34+, CD133+, and KDR+.
Positive_regulation (positive) of EPCs
2) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.18 Pain Relevance 0.09
Nevertheless, statin-mediated biphasic effect seems to be associated to a late increase of CD34+/CD144+ EPCs, which show a potential effect of statins on EPC differentiation from early to advanced progenitors (Deschaseaux et al 2007).
Positive_regulation (increase) of EPCs
3) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.32 Pain Relevance 0
Physical training in mice increased the number of circulating EPCs (Laufs et al 2004) being these results reproduced in patients (Steiner et al 2005).
Positive_regulation (increased) of EPCs
4) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.36 Pain Relevance 0.08
A single bolus of EPO has been shown to increase blood number of EPCs (CD34+/CD45?)
Positive_regulation (increase) of EPCs in blood
5) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.66 Pain Relevance 0.12

General Comments

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