INT166278

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.95
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PROM1) cilium (PROM1)
Anatomy Link Frequency
muscle 2
stem cells 2
blood 1
bone marrow 1
skeletal muscle 1
PROM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 35 98.32 Very High Very High Very High
Inflammation 32 98.12 Very High Very High Very High
Inflammatory mediators 4 65.12 Quite High
headache 3 57.92 Quite High
Migraine 3 57.52 Quite High
ischemia 13 50.00 Quite Low
Pain 3 10.00 Low Low
Potency 3 7.76 Low Low
chemokine 11 5.00 Very Low Very Low Very Low
palliative 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Dystrophy 630 99.84 Very High Very High Very High
Adhesions 70 98.40 Very High Very High Very High
Disease 129 98.20 Very High Very High Very High
INFLAMMATION 40 98.12 Very High Very High Very High
Disease Progression 64 96.52 Very High Very High Very High
Cancer 107 95.68 Very High Very High Very High
Brain Tumor 1 94.00 High High
Nicotine Addiction 6 93.72 High High
Diabetes Mellitus 12 93.16 High High
Fever 1 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apheresis was performed, obtaining 50 mL of blood with a high rate of EPCs (CD34(+) and CD133(+) cells were counted).
Positive_regulation (rate) of CD133 in blood
1) Confidence 0.49 Published 2010 Journal Ann Vasc Surg Section Body Doc Link 20142004 Disease Relevance 0 Pain Relevance 0
Augmentation of both CD133 and CD34 cells in circulation was observed, as well as KDR-1+/CD34+ EPC capable of forming endothelial colonies.
Positive_regulation (Augmentation) of CD133
2) Confidence 0.32 Published 2010 Journal J Transl Med Section Body Doc Link PMC2862021 Disease Relevance 0.19 Pain Relevance 0
While we correlated an increase in hematopoietic colonies with Stem-Kine induced upregulation of peripheral blood CD34 and CD133 cells, given that these markers are also found on EPC [25], we evaluated the possibility that circulating EPC numbers were also increased.
Positive_regulation (upregulation) of CD133 in Stem
3) Confidence 0.32 Published 2010 Journal J Transl Med Section Body Doc Link PMC2862021 Disease Relevance 0.44 Pain Relevance 0
Linear regression analysis between the levels of circulating CD133+CXCR4+CD34- cells and MRC% values showed that higher levels of CD133+CXCR4+CD34- cells corresponded to higher muscle strength (r2?
Positive_regulation (circulating) of CD133 in muscle
4) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.50 Pain Relevance 0
These data suggest that the levels of circulating CD133+CXCR4+CD34- cells could be a biomarker for DMD.
Positive_regulation (circulating) of CD133 associated with muscular dystrophy
5) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.84 Pain Relevance 0
To determine whether CD133 positive subpopulations exhibited endothelial stem cell characteristics, sorted normal and DMD CD133+ cells were plated (?
Spec (whether) Positive_regulation (subpopulations) of CD133 in stem cell associated with muscular dystrophy
6) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.24 Pain Relevance 0.03
We found that the number of CD133+CXCR4+CD34- cells with surface expression of L-selectin and VCAM-1 was markedly increased in DMD patients compared with healthy controls and with a preponderance of these cells in patients with a mild phenotype.
Positive_regulation (increased) of CD133 associated with muscular dystrophy
7) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.70 Pain Relevance 0.07
First, it has been established that endothelial progenitors can be mobilized from the bone marrow to blood in response to a variety of inflammatory cytokines like those released in dystrophic skeletal muscle tissues, which could explain the increased levels of CD133+CXCR4+CD34- stem cells in DMD patients.
Positive_regulation (increased) of CD133 in stem cells associated with inflammation, muscular dystrophy and cytokine
8) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.69 Pain Relevance 0.10
We believe all these data suggest that the circulating CD133+CXCR4+CD34- stem cells have a principal role in the vascular homeostasis of the dystrophic skeletal muscle and may partially contribute to muscle regeneration.
Positive_regulation (circulating) of CD133 in skeletal muscle
9) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.76 Pain Relevance 0.05
Moreover, we previously demonstrated that VCAM-1 blockade prevents blood-derived CD133+ accumulation in dystrophic muscle and that the VCAM-1-VLA-4 adhesion receptor pair has a critical role in the recruitment of these stem cells to dystrophic muscle vessels [16].
Positive_regulation (accumulation) of CD133 in muscle associated with adhesions
10) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.69 Pain Relevance 0.08
In a subgroup of 19 DMD patients after 24 months of follow-up, increased levels of CD133+CXCR4+CD34- cells was shown to be associated with a phenotype characterised by slower disease progression.
Positive_regulation (increased) of CD133 associated with muscular dystrophy and disease progression
11) Confidence 0.28 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2377332 Disease Relevance 0.77 Pain Relevance 0
A recent study by Wang et al. demonstrated the potential therapeutic use of targeting CD133 to direct therapy specifically towards CSCs.
Positive_regulation (targeting) of CD133
12) Confidence 0.28 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC2958340 Disease Relevance 0.97 Pain Relevance 0
Of these patients, 8 were categorized in the first group as exhibiting a percentage of CD133+CXCR4+CD34- cells localized above the threshold level for their corresponding age (mean age±SD: 9.17±3.01), while 11 patients were in the second ground, showing values below the regression line (mean age±SD: 10.91±3.04).
Positive_regulation (percentage) of CD133
13) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.35 Pain Relevance 0
Supplementation was associated with a peak increase of approximately 53% in the number of CD34 expressing cells and and a 90% increase in CD133 cells in circulation.
Positive_regulation (increase) of CD133
14) Confidence 0.19 Published 2010 Journal J Transl Med Section Body Doc Link PMC2862021 Disease Relevance 0.74 Pain Relevance 0.15
A low amount of intramyocardial bone marrow mononuclear cells is able to adhere in human series using radiolabelling methods, ranging from 9.2% for bone marrow-derived CD133+ and 6.8% for bone marrow-derived CD133+/CD34+ (Goussetis et al 2006) to 5.5% for peripheral blood-derived CD34+ at 1 hour after implantation (Blocklet et al 2006).
Positive_regulation (derived) of CD133 in bone marrow
15) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.06 Pain Relevance 0

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