INT16628

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Context Info
Confidence 0.43
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.89
Pain Relevance 6.92

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signal transducer activity (Oprm1)
Anatomy Link Frequency
brain 4
NAcc 2
sensory neurons 2
neurons 2
nociceptors 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 11 100.00 Very High Very High Very High
opioid receptor 7 100.00 Very High Very High Very High
mu opioid receptor 6 100.00 Very High Very High Very High
Nucleus accumbens 7 99.96 Very High Very High Very High
Calcium channel 2 99.96 Very High Very High Very High
Morphine 16 99.78 Very High Very High Very High
Ventral tegmentum 5 99.68 Very High Very High Very High
Dopamine 5 99.46 Very High Very High Very High
Glutamate 3 99.08 Very High Very High Very High
nociceptor 6 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 2 98.38 Very High Very High Very High
Nociception 2 97.84 Very High Very High Very High
Pain 6 88.88 High High
INFLAMMATION 2 75.00 Quite High
Nervous System Injury 1 50.92 Quite High
Opiate Addiction 1 28.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, activation of mu opioid receptor significantly inhibited the glutamatergic excitatory postsynaptic currents (EPSCs) in the anterior cingulate cortex neurons, which was attained through the suppression of presynaptic glutamate release.
Negative_regulation (inhibited) of Positive_regulation (activation) of mu opioid receptor in neurons associated with glutamate, mu opioid receptor and anterior cingulate cortex
1) Confidence 0.43 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19944678 Disease Relevance 0.15 Pain Relevance 0.99
Here, we show that activation of the mu receptor inhibits Ca2+ channels in rat sensory neurons; the effect is blocked by a mu antagonist and is not mimicked by kappa or delta receptor agonists.
Negative_regulation (inhibits) of Positive_regulation (activation) of mu receptor in sensory neurons associated with antagonist and agonist
2) Confidence 0.42 Published 1991 Journal Neuron Section Abstract Doc Link 1846076 Disease Relevance 0 Pain Relevance 0.68
Activation of the mu opioid receptor inhibited calcium channels on almost all small nociceptors but had minimal effect on large nociceptors.
Negative_regulation (inhibited) of Positive_regulation (Activation) of mu opioid receptor in nociceptors associated with nociceptor, calcium channel and mu opioid receptor
3) Confidence 0.40 Published 1995 Journal Science Section Abstract Doc Link 7481826 Disease Relevance 0.52 Pain Relevance 1.42
Previous studies have shown that chronic i.v. treatment with morphine or heroin decreased mu opioid receptor activation of G-proteins in specific brain regions.
Negative_regulation (decreased) of Positive_regulation (activation) of mu opioid receptor in brain associated with mu opioid receptor and morphine
4) Confidence 0.35 Published 2001 Journal Brain Res. Section Abstract Doc Link 11259753 Disease Relevance 0 Pain Relevance 0.87
These results indicate a complex DAMGO modulation of the NMDA component of glutamatergic synaptic transmission in NAcc: mu receptor activation decreases NMDA-EPSP amplitudes presynaptically yet increases NMDA currents postsynaptically.
Negative_regulation (decreases) of Positive_regulation (activation) of mu receptor in NAcc associated with nucleus accumbens
5) Confidence 0.31 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 8987732 Disease Relevance 0 Pain Relevance 0.68
These findings suggest that attenuation of the morphine-induced place preference under neuropathic pain may result from a decrease in the morphine-induced DA release in the N.Acc with reduction in the mu-opioid receptor-mediated G-protein activation in the VTA.
Negative_regulation (reduction) of Positive_regulation (activation) of mu-opioid receptor associated with ventral tegmentum, dopamine, neuropathic pain, opioid receptor and morphine
6) Confidence 0.22 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 12358766 Disease Relevance 0.22 Pain Relevance 1.46
Radioreceptor binding studies in rat and guinea pig brain preparations revealed that (-)-(1S,5S)-5 displayed an 11-fold decrease in affinity for the opioid mu receptor and an increase in affinity for sigma receptors of 81-fold (low nanomolar affinity) relative to the ketone precursor (+)-(1S,5S)-4.
Negative_regulation (decrease) of Positive_regulation (increase) of opioid mu receptor in brain associated with opioid
7) Confidence 0.13 Published 1994 Journal J. Med. Chem. Section Abstract Doc Link 7932540 Disease Relevance 0 Pain Relevance 0.24
However, independently of the method used to activate specific adenylyl cyclase isozymes, acute activation of the mu-opioid receptor inhibited the activity of adenylyl cyclases I, V, VI, and VIII, while types II, IV, and VII were stimulated and type III was not affected.
Negative_regulation (inhibited) of Positive_regulation (activation) of mu-opioid receptor associated with opioid receptor
8) Confidence 0.03 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9030567 Disease Relevance 0 Pain Relevance 0.21
Functionally, OFQ/N inhibits forskolin-stimulated cAMP accumulation in both the KOR-3 and the MOR-1/KOR-3 chimera by almost 40%, with IC50 values in the low nanomolar range.
Negative_regulation (inhibits) of Positive_regulation (accumulation) of MOR-1
9) Confidence 0.02 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8898097 Disease Relevance 0 Pain Relevance 0.36

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