INT16631

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Context Info
Confidence 0.57
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 46
Total Number 47
Disease Relevance 30.53
Pain Relevance 7.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APC) chromosome organization (APC) cell adhesion (APC)
plasma membrane (APC) cytoskeleton (APC) nucleus (APC)
Anatomy Link Frequency
colon 3
plasma 2
sciatic nerve 2
blood 1
PGE1 1
APC (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 13 100.00 Very High Very High Very High
Sciatic nerve 7 100.00 Very High Very High Very High
substance P 20 99.98 Very High Very High Very High
c fibre 7 99.98 Very High Very High Very High
Opioid 14 99.60 Very High Very High Very High
addiction 11 99.56 Very High Very High Very High
Potency 5 98.68 Very High Very High Very High
lidocaine 7 98.40 Very High Very High Very High
opioid receptor 4 98.40 Very High Very High Very High
antagonist 24 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 585 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 345 100.00 Very High Very High Very High
Colon Cancer 160 100.00 Very High Very High Very High
Intestinal Polyps 2 100.00 Very High Very High Very High
Hepatocellular Cancer 120 99.84 Very High Very High Very High
Adenoma 97 99.84 Very High Very High Very High
Opiate Addiction 6 99.56 Very High Very High Very High
Recurrence 5 99.52 Very High Very High Very High
Hemorrhage 20 99.16 Very High Very High Very High
Multiple Organ Failure 233 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Scavengers of reactive oxygen species (ROS) abrogate APC, suggesting an effect of anesthetic agents to cause ROS formation.
Negative_regulation (abrogate) of APC
1) Confidence 0.57 Published 2004 Journal Antioxid. Redox Signal. Section Abstract Doc Link 15025946 Disease Relevance 0.21 Pain Relevance 0.24
The PC deficiency was therefore logically associated with a decrease of APC levels in patients with MOF.
Negative_regulation (decrease) of APC associated with multiple organ failure
2) Confidence 0.55 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.81 Pain Relevance 0
Plasma samples supplemented with benzamidine, a reversible inhibitor of thrombin, APC, and trypsin-like proteases, were incubated in the wells for the capture of APC and PC.
Negative_regulation (inhibitor) of APC in Plasma
3) Confidence 0.55 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.14 Pain Relevance 0
To avoid an imbalance between APC and standard care patients from each site, each participating site enrolled in blocks of three APC and six standard care patients.
Negative_regulation (blocks) of APC
4) Confidence 0.50 Published 2007 Journal Crit Care Section Body Doc Link PMC2246225 Disease Relevance 0.44 Pain Relevance 0.06
However, allelic loss of APC has been shown to increase in frequency as there is progression towards carcinoma [69].
Negative_regulation (loss) of APC associated with familial adenomatous polyposis and carcinoma
5) Confidence 0.45 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.39 Pain Relevance 0
Turbinate reduction with APC is an alternative technique with many advantages, and the results are comparable to those of standard techniques.
Negative_regulation (reduction) of APC
6) Confidence 0.44 Published 2000 Journal Ann. Otol. Rhinol. Laryngol. Section Abstract Doc Link 11007087 Disease Relevance 0.46 Pain Relevance 0.08
These findings suggest that quantitative epigenetic changes are probably of clinical significance in hepatocarcinogenesis, but further post-transcriptional mechanisms must also be responsible for inactivation of the APC gene in HCC.
Negative_regulation (inactivation) of APC gene associated with hepatocellular cancer and familial adenomatous polyposis
7) Confidence 0.43 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.77 Pain Relevance 0.05
In summary, APC gene mutations do not seem to play an important role in the inactivation of APC in HCC.
Negative_regulation (inactivation) of APC associated with hepatocellular cancer and familial adenomatous polyposis
8) Confidence 0.43 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.77 Pain Relevance 0
Severe glutathione synthetase (GS) deficiency is a rare genetic disorder with neonatal onset.
Negative_regulation (deficiency) of GS
9) Confidence 0.42 Published 1997 Journal Hum. Mol. Genet. Section Abstract Doc Link 9215686 Disease Relevance 0.31 Pain Relevance 0.11
Enhanced stimulatory adenylyl cyclase signaling during opioid dependence is associated with a reduction in palmitoylated Gs alpha.
Negative_regulation (reduction) of Gs alpha associated with addiction and opioid
10) Confidence 0.41 Published 1997 Journal Mol. Pharmacol. Section Title Doc Link 9415709 Disease Relevance 0.29 Pain Relevance 0.47
Inactivation of the APC tumour-suppressor gene, and the activation of K-ras, have a combined effect on increasing tissue polyamine contents due to increased synthesis and decreased catabolism of the polyamines.
Negative_regulation (Inactivation) of APC tumour-suppressor gene associated with cancer and familial adenomatous polyposis
11) Confidence 0.41 Published 2003 Journal Biochem. Soc. Trans. Section Abstract Doc Link 12653645 Disease Relevance 0.73 Pain Relevance 0.22
Thrombin is the APC activator, and APC is a feedback inhibitor for thrombin generation [22,23].
Negative_regulation (inhibitor) of APC
12) Confidence 0.40 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.59 Pain Relevance 0
During cardiopulmonary bypass, upon rapid thrombin generation during reperfusion, the APC/PC correlation was lost and a significant positive correlation between fibrinopetide A, a thrombin marker, and APC developed [24].
Negative_regulation (lost) of APC
13) Confidence 0.40 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.33 Pain Relevance 0
Using 87% as the cut-off value, 8/13 (62%) cases and 3/18 (17%) controls showed reduced APC levels (P = 0.021).
Negative_regulation (reduced) of APC
14) Confidence 0.40 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1550818 Disease Relevance 1.03 Pain Relevance 0.06
Therefore, in good accordance with the study by Liaw and colleagues in adult septic patients [28], we assume that the lack of elevated free APC levels in the presence of activated coagulation in patients with AP in most cases reflected dysfunctional PC activation on the endothelium, or possibly enhanced inhibition of APC by plasma protease inhibitors.
Negative_regulation (inhibition) of APC in plasma associated with pancreatitis
15) Confidence 0.40 Published 2006 Journal Crit Care Section Body Doc Link PMC1550818 Disease Relevance 0.70 Pain Relevance 0
It has been shown that the half-life of aPC is decreased when administered to species different from human [17].
Negative_regulation (decreased) of aPC
16) Confidence 0.40 Published 2006 Journal Crit Care Section Body Doc Link PMC1550919 Disease Relevance 0.25 Pain Relevance 0.03
The amount of lidocaine required at steady state to double the firing threshold of single fibers or to reduce the peak of the APc by 40% was used as the index of potency.
Negative_regulation (reduce) of APc associated with action potential, lidocaine and potency
17) Confidence 0.37 Published 1987 Journal Anesth. Analg. Section Abstract Doc Link 3099602 Disease Relevance 0 Pain Relevance 0.81
The blood loss was 90% decreased in the TE(APC) compared with the TE(Conv) in both age groups (P <.01).
Negative_regulation (decreased) of APC in blood
18) Confidence 0.37 Published 2001 Journal Laryngoscope Section Body Doc Link 11568579 Disease Relevance 0 Pain Relevance 0
Overexpression of SND1 in colon cancer cells caused down-regulation of APC and activation of the Wnt signaling pathway as a consequence, without altering APC mRNA levels.
Negative_regulation (regulation) of APC in colon associated with familial adenomatous polyposis and colon cancer
19) Confidence 0.37 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 0.99 Pain Relevance 0
Inactivation of the APC protein is responsible for both inherited and sporadic types of CRC.
Negative_regulation (Inactivation) of APC associated with colorectal cancer and familial adenomatous polyposis
20) Confidence 0.37 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.43 Pain Relevance 0

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