INT166312

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.90
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vim) structural molecule activity (Vim) plasma membrane (Vim)
cytoskeleton (Vim) nucleus (Vim) biological_process (Vim)
Anatomy Link Frequency
ligaments 1
spindle cells 1
smooth muscle 1
Vim (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 8 86.40 High High
nud 1 86.04 High High
anesthesia 1 83.60 Quite High
abdominal pain 1 82.44 Quite High
pain flank 1 75.72 Quite High
positron emission tomography 1 68.28 Quite High
imagery 8 55.64 Quite High
headache 1 41.96 Quite Low
Nerve growth factor 1 6.36 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 48 99.70 Very High Very High Very High
Hyperplasia 4 99.38 Very High Very High Very High
Leiomyosarcoma 13 99.26 Very High Very High Very High
Nerve Sheath Neoplasms 9 98.84 Very High Very High Very High
Skin Cancer 5 98.64 Very High Very High Very High
Hemangioma 4 95.92 Very High Very High Very High
Brain Tumor 1 95.68 Very High Very High Very High
Malignant Neoplastic Disease 12 92.80 High High
Vascular Neoplasms 1 90.08 High High
Nevus 1 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon immunohistochemistry, the epithelial tumor was positive for cytokeratin and negative for vimentin and the endothelial tumor was negative for cytokeratin and positive for vimentin.
Negative_regulation (positive) of vimentin associated with cancer
1) Confidence 0.22 Published 2010 Journal Vet Ophthalmol Section Abstract Doc Link 20149179 Disease Relevance 1.00 Pain Relevance 0.08
Although no tumor cells contained apparent brown pigment, most were found to be positive for S-100 protein, HMB-45, Melan-A, and vimentin.
Negative_regulation (positive) of vimentin associated with cancer
2) Confidence 0.10 Published 2010 Journal Turk J Gastroenterol Section Abstract Doc Link 20533113 Disease Relevance 1.29 Pain Relevance 0.08
Immunohistochemistry was positive for CD34, vimentin; and negative for GFAP (glial fibrillary acidic protein) and SMA (smooth muscle actin).
Negative_regulation (positive) of vimentin in smooth muscle
3) Confidence 0.03 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1654154 Disease Relevance 0.95 Pain Relevance 0.16
Pathological examination revealed hypercellularity of spindle cells, that showed positive for CD34, vimentin, desmin and Mic-2, and negative for S100, alphaSMA, c-kit, AE1/3, p53 and bcl-2.
Negative_regulation (positive) of vimentin in spindle cells associated with hyperplasia
4) Confidence 0.03 Published 2010 Journal Hinyokika Kiyo Section Abstract Doc Link 20610922 Disease Relevance 0.66 Pain Relevance 0.08
Application of a judicious immunohistochemical panel is useful, especially in the distinction of cervical MPNST from leiomyosarcomas, as the former tumors are generally positive for S100 and vimentin and are negative for desmin, myoglobin and actin [36].
Negative_regulation (positive) of vimentin associated with leiomyosarcoma, nerve sheath neoplasms and cancer
5) Confidence 0.03 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1584249 Disease Relevance 1.36 Pain Relevance 0
Similarly, transfer of IGF-1 cDNA by using an adenovirus vector led to the synthesis and deposition of increased amounts of types I and III collagen, elastin, tenascin, and vimentin in the same model[111]; thus confirming the potential of using vector-laden hydrogels for the in situ delivery of genes to damaged ligaments for potential biological repair of the ACL.


Negative_regulation (amounts) of vimentin in ligaments
6) Confidence 0.02 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2879239 Disease Relevance 0.07 Pain Relevance 0
Immunostains for vimentin and alpha-SMA are usually positive, but desmin, cytokeratin and S-100 are typically negative.
Negative_regulation (positive) of vimentin
7) Confidence 0.02 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2971489 Disease Relevance 0.58 Pain Relevance 0.06

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