INT166356

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.00
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPD1) cytosol (HSPD1) mitochondrion (HSPD1)
extracellular space (HSPD1) cell death (HSPD1) ATPase activity (HSPD1)
Anatomy Link Frequency
Apoptotic cells 1
HSPD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 52 89.40 High High
Inflammatory response 12 63.48 Quite High
rheumatoid arthritis 13 54.40 Quite High
Arthritis 2 42.84 Quite Low
cytokine 3 8.96 Low Low
cINOD 3 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 45 100.00 Very High Very High Very High
Disease 89 99.90 Very High Very High Very High
Periodontal Disease 8 99.66 Very High Very High Very High
Cardiovascular Disease 53 99.50 Very High Very High Very High
Diabetes Mellitus 35 95.44 Very High Very High Very High
Stroke 3 90.04 High High
INFLAMMATION 68 89.40 High High
Myocardial Infarction 8 89.00 High High
Death 10 87.16 High High
Periodontitis 19 80.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apoptotic cells were also reduced in HSP60-overexpressing.
Negative_regulation (reduced) of HSP60-overexpressing in Apoptotic cells
1) Confidence 0.55 Published 2010 Journal Life Sci. Section Body Doc Link 20159025 Disease Relevance 0 Pain Relevance 0
If HSP10 synthesis did decrease in periodontal disease a corresponding decrease in HSP60 concentrations would be expected, and was not observed in this study.
Negative_regulation (decrease) of HSP60 associated with periodontal disease
2) Confidence 0.49 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2065903 Disease Relevance 0.63 Pain Relevance 0.16
Table 4 provides information on the occurrence of secondary CVD in relation to the sero-prevalence of CP, Ch-hsp60 and h-hsp60.
Negative_regulation (prevalence) of Ch-hsp60 associated with cardiovascular disease
3) Confidence 0.23 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1458355 Disease Relevance 1.51 Pain Relevance 0
Moreover, HO-1 expression in PBMCs from patients with Beh├žet's disease was repressed in the presence of either lipopolysaccharide or heat shock protein-60.


Negative_regulation (repressed) of heat shock protein-60 associated with shock and disease
4) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2374472 Disease Relevance 0.86 Pain Relevance 0.06

General Comments

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