INT166360

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.36
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (Pomc) cytoplasm (Pomc) response to stress (Crhr1)
signal transducer activity (Crhr1) signal transduction (Pomc) extracellular space (Pomc)
Anatomy Link Frequency
plasma 3
Crhr1 (Rattus norvegicus)
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 10 100.00 Very High Very High Very High
Morphine 9 100.00 Very High Very High Very High
narcan 3 98.44 Very High Very High Very High
noradrenaline 4 94.56 High High
antagonist 3 92.16 High High
addiction 1 46.28 Quite Low
Disease Link Frequency Relevance Heat
Weight Loss 1 87.64 High High
Body Weight 1 87.44 High High
Stress 5 75.00 Quite High
Drug Dependence 1 46.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, blockade of CRF1R significantly reduced morphine withdrawal-induced increases in plasma adrenocorticotropin levels.
Negative_regulation (blockade) of CRF1R in plasma Negative_regulation (reduced) of Positive_regulation (increases) of adrenocorticotropin in plasma associated with withdrawal and morphine
1) Confidence 0.02 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20159948 Disease Relevance 0.36 Pain Relevance 1.50

General Comments

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