INT166378

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 13
Disease Relevance 1.94
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pick1) protein targeting (Pick1) Golgi apparatus (Pick1)
ATPase activity (Pick1) plasma membrane (Pick1) enzyme binding (Pick1)
Anatomy Link Frequency
frontal cortex 7
Mouse 2
nucleus accumbens 1
striatum 1
hippocampus 1
Pick1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 45 99.76 Very High Very High Very High
Hippocampus 10 98.56 Very High Very High Very High
Nucleus accumbens 15 97.92 Very High Very High Very High
Dopamine 16 97.44 Very High Very High Very High
ASIC 88 78.52 Quite High
Glutamate 8 53.40 Quite High
imagery 24 51.60 Quite High
Neuropeptide 10 25.00 Low Low
Kinase C 8 22.96 Low Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 15 100.00 Very High Very High Very High
Toxicity 48 99.80 Very High Very High Very High
Acidosis 32 98.92 Very High Very High Very High
Disease 32 86.84 High High
Death 64 86.32 High High
Apoptosis 8 83.20 Quite High
Targeted Disruption 8 63.44 Quite High
Pain 8 5.00 Very Low Very Low Very Low
Neurological Disease 8 5.00 Very Low Very Low Very Low
Demyelinating Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We transfected ASIC1a, with or without PICK1, into COS7 cells.
Positive_regulation (transfected) of Gene_expression (transfected) of PICK1
1) Confidence 0.61 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.54 Pain Relevance 0
In contrast to wild-type PICK1, when PICK 2K-E mutant was co-transfected with ASIC1a in 293T cells, we did not observe any cluster formation (Figure 2C).
Positive_regulation (transfected) of Gene_expression (transfected) of PICK
2) Confidence 0.49 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0
PNGase treatment reduced all slower migrating species to the faster migrating species in both control and PICK1 overexpressing conditions.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PICK1
3) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0
Co-expressing of PICK1 with mouse ASIC1a also increased the population of faster migrating ASIC1a (Figure 1D).
Positive_regulation (increased) of Gene_expression (expressing) of PICK1
4) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0
In contrast, overexpression of PICK1 decreases surface expression of AMPA receptors [31,33,36,51] and netrin-1 receptor UNC5H1 [52].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PICK1
5) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.06 Pain Relevance 0.08
Mouse ASIC1a was co-transfected with eGFP or GFP-PICK1.
Positive_regulation (transfected) of Gene_expression (transfected) of PICK1 in Mouse
6) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.17 Pain Relevance 0.03
Here, we show that PICK1 overexpression increases ASIC1a surface level.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PICK1
7) Confidence 0.41 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC3018362 Disease Relevance 0.17 Pain Relevance 0.04
We co-transfected ASIC1a with wild-type PICK1 or BAR-domain mutant PICK1 2K-E into HEK293T cells.
Positive_regulation (transfected) of Gene_expression (transfected) of PICK1
8) Confidence 0.38 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of Gene_expression (levels) of C-kinase 1 protein in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
9) Confidence 0.15 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (induces) of Gene_expression (levels) of C-kinase 1 protein in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
10) Confidence 0.15 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of in nucleus accumbens Gene_expression (levels) of C-kinase 1 protein in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
11) Confidence 0.05 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of in hippocampus Gene_expression (levels) of C-kinase 1 protein in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
12) Confidence 0.05 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of in striatum Gene_expression (levels) of C-kinase 1 protein in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
13) Confidence 0.05 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52

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