INT166380

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 1.26
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pick1) protein targeting (Pick1) Golgi apparatus (Pick1)
ATPase activity (Pick1) plasma membrane (Pick1) enzyme binding (Pick1)
Anatomy Link Frequency
nucleus accumbens 1
striatum 1
frontal cortex 1
hippocampus 1
Pick1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 36 99.02 Very High Very High Very High
Hippocampus 8 94.28 High High
Nucleus accumbens 12 93.64 High High
Glutamate 4 89.08 High High
ASIC 44 79.76 Quite High
Kinase C 4 48.00 Quite Low
Neuropeptide 8 25.00 Low Low
imagery 12 5.00 Very Low Very Low Very Low
Dopamine 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 12 99.24 Very High Very High Very High
Acidosis 16 78.00 Quite High
Death 32 76.24 Quite High
Toxicity 24 75.92 Quite High
Disease 16 63.40 Quite High
Brain Injury 4 62.60 Quite High
Pain 4 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Demyelinating Disease 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result indicates that lipid binding is required for PICK1-regulated surface expression of ASIC1a.
Positive_regulation (required) of PICK1
1) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
In addition, and similar to our earlier studies on AMPA receptors [36], the effect of PICK1 on ASIC1a localization and surface also requires the lipid binding of PICK1.
Positive_regulation (requires) of PICK1
2) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.48 Pain Relevance 0.08
Lipid binding is required for PICK1-induced clustering of ASIC1a
Positive_regulation (required) of PICK1
3) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
PICK1-regulated surface expression of ASIC1a is dependent on the lipid binding of PICK1's BAR domain
Positive_regulation (dependent) of PICK1
4) Confidence 0.44 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of C-kinase 1 protein in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
5) Confidence 0.20 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.19 Pain Relevance 0.44
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of C-kinase 1 protein in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
6) Confidence 0.07 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.19 Pain Relevance 0.44
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of C-kinase 1 protein in nucleus accumbens associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
7) Confidence 0.07 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.19 Pain Relevance 0.44
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of C-kinase 1 protein in hippocampus associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
8) Confidence 0.07 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.19 Pain Relevance 0.44

General Comments

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