INT166383

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 10
Disease Relevance 2.19
Pain Relevance 7.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnb2l1) cytoskeleton (Gnb2l1) nucleus (Gnb2l1)
cell cycle (Gnb2l1) cytoplasm (Gnb2l1)
Anatomy Link Frequency
frontal cortex 9
striatum 7
nucleus accumbens 1
hippocampus 1
Gnb2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 20 99.84 Very High Very High Very High
Morphine 90 99.76 Very High Very High Very High
Nucleus accumbens 30 99.20 Very High Very High Very High
Neuropeptide 20 25.00 Low Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 30 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study is to investigate the effect of overexpression of RACK1 on the conditioned place preference (CPP) and the level of p-ERK in morphine reexposure mice.
Spec (investigate) Positive_regulation (overexpression) of Gene_expression (overexpression) of RACK1 associated with morphine
1) Confidence 0.69 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.68
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of Gene_expression (levels) of RACK1 in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
2) Confidence 0.50 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (induces) of Gene_expression (levels) of RACK1 in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
3) Confidence 0.50 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Positive_regulation (increased) of Gene_expression (level) of RACK1 in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
4) Confidence 0.50 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.94
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Positive_regulation (increased) of Gene_expression (level) of RACK1 in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
5) Confidence 0.50 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.93
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Positive_regulation (increased) of in frontal cortex Gene_expression (level) of RACK1 in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
6) Confidence 0.17 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.94
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of in nucleus accumbens Gene_expression (levels) of RACK1 in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
7) Confidence 0.17 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of in hippocampus Gene_expression (levels) of RACK1 in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
8) Confidence 0.17 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52
It was found that morphine reexposured mice showed a decreased RACK1 level in the frontal cortex, striatum and an increased RACK1 level in hippocampus and NAcc, but this effect was reversed after administration of RACK1.
Positive_regulation (increased) of in frontal cortex Gene_expression (level) of RACK1 in striatum associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
9) Confidence 0.17 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.24 Pain Relevance 0.93
Morphine reexposure induces the decrease of receptor for activated C-kinase 1 protein (RACK1) levels in frontal cortex, and the increase of p-ERK (extracellular signal-regulated kinase) levels in mouse frontal cortex, striatum, hippocampus and nucleus accumbens (NAcc).
Positive_regulation (activated) of in striatum Gene_expression (levels) of RACK1 in frontal cortex associated with nucleus accumbens, urological neuroanatomy, hippocampus and morphine
10) Confidence 0.17 Published 2009 Journal Arch Ital Biol Section Abstract Doc Link 20162862 Disease Relevance 0.20 Pain Relevance 0.52

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