INT1664

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Context Info
Confidence 0.65
First Reported 1979
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 13.63
Pain Relevance 7.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Kitl) extracellular region (Kitl) cell adhesion (Kitl)
plasma membrane (Kitl) cytoskeleton (Kitl) cytoplasm (Kitl)
Anatomy Link Frequency
stem cell 3
macrophage 1
liver 1
brains 1
DC101 1
Kitl (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 154 100.00 Very High Very High Very High
Central grey 31 100.00 Very High Very High Very High
analgesia 21 100.00 Very High Very High Very High
midbrain 1 99.98 Very High Very High Very High
Morphine 65 99.62 Very High Very High Very High
electroacupuncture 10 99.52 Very High Very High Very High
Enkephalin 19 99.40 Very High Very High Very High
Inflammatory mediators 3 98.68 Very High Very High Very High
Osteoarthritis 34 98.56 Very High Very High Very High
Inflammation 228 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 154 100.00 Very High Very High Very High
Urological Neuroanatomy 31 100.00 Very High Very High Very High
Cytomegalovirus Infection 11 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 334 99.98 Very High Very High Very High
Stress 134 99.90 Very High Very High Very High
Infection 453 99.48 Very High Very High Very High
Skin Cancer 18 98.82 Very High Very High Very High
Targeted Disruption 57 98.80 Very High Very High Very High
Osteoarthritis 34 98.56 Very High Very High Very High
Cancer 575 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of HDL-C on endothelial function and integrity
Gene_expression (function) of C on associated with disorder of lipid metabolism
1) Confidence 0.65 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.85 Pain Relevance 0.20
Since previous studies have shown the ability of antioxidants to modify gene expression of pro-inflammatory mediators in activated microglia [31,45], we studied the effects of Trolox C on LPS-induced COX-2 and mPGES-1 expression.
Gene_expression (expression) of C on in microglia associated with inflammatory mediators
2) Confidence 0.65 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0.10 Pain Relevance 0.05
Consistently, KIT and KITL were found to be expressed in the rat cholangiocytes [9] and several mouse mutants of Kitl displayed comparable low post-natal viability [46,47].


Gene_expression (expressed) of KITL
3) Confidence 0.57 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.37 Pain Relevance 0
The K14-SCF transgenic murine model of variant pigmentation is based on epidermal expression of stem cell factor (SCF) on the C57BL/6J background.
Gene_expression (expression) of stem cell factor in stem cell associated with targeted disruption
4) Confidence 0.47 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19682281 Disease Relevance 0.18 Pain Relevance 0.07
As controls wild-type endothelial cells transfected with Con siRNA and treated with DC101 showed baseline migration and this was further inhibited in similarly treated ?
Gene_expression (transfected) of Con in DC101
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
Additionally, using a second approach, VEGF-induced angiogenesis in scrambled control-siRNA (Con siRNA) injected sponges in ?
Gene_expression (siRNA) of Con
6) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.06 Pain Relevance 0
Consistently, KIT and KITL were found to be expressed in the rat cholangiocytes [9] and several mouse mutants of Kitl displayed comparable low post-natal viability [46,47].


Gene_expression (expressed) of Kitl
7) Confidence 0.44 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.38 Pain Relevance 0
One day before setting up the 3D migration assays, Con- and Rac1- siRNA transfected ?
Gene_expression (transfected) of Con
8) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.13 Pain Relevance 0
Results also showed that although pSico-Flk-1 treatment reduced significantly B16F0 melanoma size (P<0.05) in both genotypes, when compared with pSico-Con controls, pSico-Rac1-treatment did not affect tumor size in wild-type/Tie1-Cre+ mice, but significantly reduced tumor size in ?
Gene_expression (controls) of Con associated with cancer and skin cancer
9) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.76 Pain Relevance 0
However, the phase of the circadian rhythm of mPER1 expression in the brains of MD mice significantly differed from that of the Con mice (p < 0.05).
Gene_expression (expression) of Con in brains
10) Confidence 0.36 Published 2006 Journal J Circadian Rhythms Section Abstract Doc Link PMC1563481 Disease Relevance 0.21 Pain Relevance 0.76
Importantly, the adjustment at the gene level is efficacious only up to a certain degree of cholesterol stress: while low loads of cholesterol are fully absorbed (consider the comparable intrahepatic lipidome fingerprints for the LC and Con groups), exposure to high loads of dietary cholesterol in the HC group significantly altered the liver lipidome, despite further intensified adjustment of gene expression.
Gene_expression (groups) of Con in liver associated with stress, inflammation and disorder of lipid metabolism
11) Confidence 0.18 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.33 Pain Relevance 0.19
Mast cell-fibroblast interactions have been shown to be required for BMMC to secrete CCL11 (eotaxin-1), mediated via transmembrane expression of stem cell factor (SCF) by the fibroblast [49].
Gene_expression (expression) of stem cell factor in Mast cell
12) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914748 Disease Relevance 0.44 Pain Relevance 0.09
The immune responses of mice injected with plasmids VR-gB and VR-gB Delta tm expressing the full-length membrane-anchored, or secreted forms of human cytomegalovirus (HCMV)-glycoprotein B (gB), respectively, and VR-pp65 expressing the HCMV-phosphoprotein 65 (pp65) were analyzed.
Gene_expression (expressing) of gB associated with cytomegalovirus infection
13) Confidence 0.12 Published 2001 Journal Vaccine Section Abstract Doc Link 11427273 Disease Relevance 0.45 Pain Relevance 0.09
Mock-infected cells did not express gB and the control antibody against ?
Neg (not) Gene_expression (express) of gB
14) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606062 Disease Relevance 0.14 Pain Relevance 0
/IL-10 ratio after Con-A stimulation in whole blood cells on post-operative day 1, and SOCS-3 gene expression on post-operative day 2 were significantly lower in the remifentanil group than in the fentanyl group.
Gene_expression (expression) of Con in blood cells associated with ultiva
15) Confidence 0.10 Published 2010 Journal Crit Care Section Body Doc Link PMC2887136 Disease Relevance 0.47 Pain Relevance 0.65
The immune responses of mice injected with plasmids VR-gB and VR-gB Delta tm expressing the full-length membrane-anchored, or secreted forms of human cytomegalovirus (HCMV)-glycoprotein B (gB), respectively, and VR-pp65 expressing the HCMV-phosphoprotein 65 (pp65) were analyzed.
Gene_expression (expressing) of gB associated with cytomegalovirus infection
16) Confidence 0.10 Published 2001 Journal Vaccine Section Abstract Doc Link 11427273 Disease Relevance 0.45 Pain Relevance 0.09
Also in the present study, sequence analysis of EHV-1 viral DNA isolated from lungs of siRNA–treated infected mice did not show any mutations in the targeted gB and Ori genes (data not shown), indicating that escape mutation might not be as concerning for DNA viruses.
Gene_expression (targeted) of gB in lungs
17) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606062 Disease Relevance 0.45 Pain Relevance 0.09
Purified KSL cells from C57BL/6 bone marrow were irradiated with 3 Gy and cultured with 5 nM of rhGH in the presence of thrombopoietin, stem cell factor, and Flt3 ligand (TSF).
Gene_expression (presence) of stem cell factor in stem cell
18) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886847 Disease Relevance 0.21 Pain Relevance 0
To detect gB, mAb 3F6 was used at a 1?
Gene_expression (detect) of gB in 3F6
19) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606062 Disease Relevance 0.44 Pain Relevance 0
We concluded from the data that siRNA treatment targeting EHV-1 gB or Ori can significantly reduce EHV-1 infection by effectively silencing gB or Ori expression at the mRNA and protein level.
Gene_expression (expression) of gB associated with infection
20) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2606062 Disease Relevance 0.10 Pain Relevance 0

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