INT166411

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.84
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
interneurons 2
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 169 99.98 Very High Very High Very High
agonist 131 99.74 Very High Very High Very High
tolerance 105 99.04 Very High Very High Very High
Analgesic 133 97.60 Very High Very High Very High
antinociception 22 97.60 Very High Very High Very High
depression 83 94.80 High High
antidepressant 66 92.56 High High
antagonist 10 91.24 High High
fluoxetine 10 87.32 High High
GABAergic 30 79.28 Quite High
Disease Link Frequency Relevance Heat
Ataxia 1 96.68 Very High Very High Very High
Depression 92 94.80 High High
Targeted Disruption 18 88.32 High High
Vomiting 1 70.64 Quite High
Cancer Pain 1 68.08 Quite High
Neurodegenerative Disease 15 67.04 Quite High
Hypothermia 5 63.60 Quite High
INFLAMMATION 1 39.60 Quite Low
Pain 10 36.64 Quite Low
Urological Neuroanatomy 21 8.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used recently generated conditional mutant mice for the CB1 receptor, bearing a deletion of the CB1 gene in principal neurons (defined as projecting neurons as opposed to interneurons, independently of their neurochemical characteristics, normally expressing Ca2+/calmodulin-dependent kinase II?
Positive_regulation (bearing) of Negative_regulation (deletion) of CB1 in interneurons
1) Confidence 0.50 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2001214 Disease Relevance 0 Pain Relevance 0.37
This study has shown that acute icv administration of cannabinoids promotes a long-lasting and robust desensitization of supraspinal CB1Rs, which could be mediated by post-receptor events.
Positive_regulation (mediated) of Negative_regulation (desensitization) of CB1Rs associated with cannabinoid
2) Confidence 0.46 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.06 Pain Relevance 0.48
This study has shown that acute icv administration of cannabinoids promotes a long-lasting and robust desensitization of supraspinal CB1Rs, which could be mediated by post-receptor events.
Positive_regulation (promotes) of Negative_regulation (desensitization) of CB1Rs associated with cannabinoid
3) Confidence 0.46 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.06 Pain Relevance 0.45
In an attempt to provide an explanation for these conflicting results, further investigations aimed at evaluating the effect of the increase of CB 1 activation and CB1 receptor blockade under identical experimental conditions and assessing the activation and blockade of CB1 receptors in different animal models of depression should be performed.
Positive_regulation (increase) of Negative_regulation (blockade) of CB1 associated with depression
4) Confidence 0.44 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.39 Pain Relevance 0.47
In wild-type mice, repeated administration of the cannabinoid agonist WIN55,212-2 promoted downregulation of CB1 receptor levels and concomitant tolerance to the effects of drug on antinociception, motor incoordination, and locomotor hypoactivity.
Positive_regulation (promoted) of Negative_regulation (downregulation) of CB1 receptor associated with antinociception, ataxia, cannabinoid, tolerance and agonist
5) Confidence 0.25 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20164830 Disease Relevance 0.32 Pain Relevance 0.85

General Comments

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