INT166412

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Context Info
Confidence 0.99
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.90
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
granule cells 1
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 146 99.48 Very High Very High Very High
Cannabinoid 151 96.86 Very High Very High Very High
Analgesic 122 96.24 Very High Very High Very High
tolerance 105 91.64 High High
GABAergic 5 82.52 Quite High
Cancer pain 1 81.60 Quite High
antinociception 21 71.80 Quite High
opioid receptor 10 67.28 Quite High
Hippocampus 11 59.04 Quite High
Neurotransmitter 1 58.40 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 20 98.16 Very High Very High Very High
Convulsion 34 85.28 High High
Status Epilepticus 37 84.32 Quite High
Vomiting 1 84.16 Quite High
Cancer Pain 1 81.60 Quite High
Epilepsy 51 74.88 Quite High
Hypothermia 2 70.96 Quite High
Ataxia 1 65.52 Quite High
Targeted Disruption 3 60.48 Quite High
Bordatella Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings indicate that the CB1R is being lysosomally degraded [9].
Protein_catabolism (degraded) of CB1R
1) Confidence 0.99 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 0.37
The cannabinoid 1 (CB1) receptors can be downregulated in vitro through an interaction with the G-protein-coupled receptor-associated sorting protein1, GASP1, that targets CB1 receptors for degradation after their agonist-mediated endocytosis.
Protein_catabolism (degradation) of CB1 associated with cannabinoid and agonist
2) Confidence 0.96 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20164830 Disease Relevance 0.29 Pain Relevance 0.81
This suggests that CB1R could be made in the cell body of the granule cells and be trafficked to the terminals.
Protein_catabolism (made) of CB1R in granule cells
3) Confidence 0.88 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.44 Pain Relevance 0.23
Most of the internalized CB1Rs bind to GASP1 and are then degraded in the lysosomal compartment [8,9].
Protein_catabolism (degraded) of CB1Rs
4) Confidence 0.65 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.17 Pain Relevance 0.97

General Comments

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