INT166414

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
nucleus (Gprasp1) signal transducer activity (Cnr1) cytoplasm (Gprasp1)
Gprasp1 (Mus musculus)
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 7 96.36 Very High Very High Very High
antinociception 1 90.56 High High
agonist 3 85.48 High High
Cannabinoid 6 85.16 High High
Cancer pain 1 54.08 Quite High
Analgesic 2 52.84 Quite High
Pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 93.72 High High
Ataxia 1 91.44 High High
Vomiting 1 56.64 Quite High
Cancer Pain 1 54.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, this study provides evidence that GASP1 regulates CB1 receptor downregulation in vivo, and that postendocytic receptor trafficking has a key role in the development of tolerance to WIN55,212-2.
GASP1 Regulation (regulates) of Negative_regulation (downregulation) of CB1 receptor associated with tolerance
1) Confidence 0.37 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20164830 Disease Relevance 0.30 Pain Relevance 0.75

General Comments

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