INT166415

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.89
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dentin 4
plasma 2
alp (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.80 Very High Very High Very High
aspirin 42 98.96 Very High Very High Very High
dexamethasone 4 87.60 High High
Bile 66 62.80 Quite High
Inflammation 10 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 5 99.36 Very High Very High Very High
Toxicity 12 97.44 Very High Very High Very High
Necrosis 3 81.84 Quite High
Stress 2 75.00 Quite High
Acute Liver Failure 1 75.00 Quite High
Overdose 2 70.96 Quite High
Injury 4 69.68 Quite High
Osteoporosis 46 50.00 Quite Low
Death 28 44.96 Quite Low
Apoptosis 27 39.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Positive_regulation (elevated) of Gene_expression (levels) of ALP in dentin
1) Confidence 0.32 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.04
After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).
Positive_regulation (elevated) of Gene_expression (expression) of ALP in dentin
2) Confidence 0.23 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.04
The underlying mechanisms of aspirin effect on bone metabolism appear to correlate with increased expression of certain osteogenic genes including Runx2, a master gene for osteogenic differentiation, ALP, and OCN (Fig. 3O).
Positive_regulation (increased) of Gene_expression (expression) of ALP associated with aspirin
3) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440798 Disease Relevance 0 Pain Relevance 0.47
APAP exposure increased the plasma levels of ALT, ALP, LDH, TNF-alpha and NO production.
Positive_regulation (increased) of Gene_expression (levels) of ALP in plasma associated with paracetamol
4) Confidence 0.04 Published 2010 Journal Free Radic. Res. Section Abstract Doc Link 20166895 Disease Relevance 0.63 Pain Relevance 0.73
Chitosan and PEI increased the AST, ALT, and ALP levels significantly at early time points, but PEI showed much higher toxicity/damage than chitosan (ALT and AST levels in PEI group were 3 times higher than that of chitosan group on the first day).
Positive_regulation (increased) of Gene_expression (levels) of ALP associated with toxicity
5) Confidence 0.03 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC1828073 Disease Relevance 0.26 Pain Relevance 0.03

General Comments

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