INT166433

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 2.82
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atp2a2) endoplasmic reticulum (Atp2a2) protein complex (Atp2a2)
Anatomy Link Frequency
cardiac myocytes 3
myocardium 2
reticulum 1
Atp2a2 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 4 97.04 Very High Very High Very High
fibrosis 10 65.40 Quite High
anesthesia 9 65.08 Quite High
TRP channel 50 50.00 Quite Low
agonist 5 49.12 Quite Low
Catecholamine 9 38.80 Quite Low
Pain 1 6.16 Low Low
ketamine 14 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 136 100.00 Very High Very High Very High
Coronary Heart Disease 18 88.40 High High
Arrhythmia Under Development 13 78.80 Quite High
Bacillus Anthracis Infection 112 73.12 Quite High
Death 35 71.96 Quite High
Disease 170 69.92 Quite High
Apoptosis 10 69.84 Quite High
Fibrosis 9 65.40 Quite High
Heart Rate Under Development 9 60.08 Quite High
Cognitive Disorder 15 55.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High-intensity exercise training in mice with cardiomyocyte-specific disruption of Serca2.
Gene_expression (disruption) of Serca2 in cardiomyocyte
1) Confidence 0.68 Published 2010 Journal J. Appl. Physiol. Section Title Doc Link 20167673 Disease Relevance 0 Pain Relevance 0.07
Indeed, calcineurin-NFAT activation was directly tied to expression of SERCA2 in cardiac myocytes (43).
Gene_expression (expression) of SERCA2 in cardiac myocytes
2) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.27 Pain Relevance 0.03
Given that intracellular Ca2+ homeostasis is tightly regulated by a cascade of intracellular Ca2+ regulatory proteins including SERCA, phospholamban (PLB) and NCX [18], Western blot analysis was performed to evaluate the expression of SERCA2a, PLB and NCX.
Gene_expression (expression) of SERCA2a
3) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.24 Pain Relevance 0
The unchanged intracellular Ca2+ decay coincides with the normal TR50 and TR90 in APP/PS1 mouse cardiomyocytes, which is also supported by the normal protein levels of SERCA2a and NCX, the main machineries to remove Ca2+ from cytosolic space for cardiac relaxation to occur, in APP/PS1 myocardium.
Gene_expression (levels) of SERCA2a in myocardium
4) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.31 Pain Relevance 0
Recently, the upregulation of TRPC4 and C5 was shown in cardiomyocytes in response to inhibition of SERCA expression.
Gene_expression (expression) of SERCA in cardiomyocytes
5) Confidence 0.12 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1557673 Disease Relevance 0.05 Pain Relevance 0
Our results shown in Fig. 5 revealed a significantly reduced expression of PLB associated with unchanged SERCA2a and NCX in myocardium from APP/PS1 mice compared with the WT group.
Gene_expression (expression) of SERCA2a in myocardium
6) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.26 Pain Relevance 0
Somewhat surprisingly, prolonged in vivo exposure (18 hrs) failed to significantly affect expression of SERCA and phospholamban, suggesting presence of compensatory mechanism or time-dependence in lethal toxin-induced response on Ca2+ regulatory proteins.
Gene_expression (expression) of SERCA associated with addiction
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.21 Pain Relevance 0.05
In vitro exposure of lethal toxin (5 nM. 2 hrs) significantly down-regulated and up-regulated the expression of SERCA2a and phospholamban, respectively, the effects of which were partially restored or ablated by apocynin pretreatment (Fig. 9).


Gene_expression (expression) of SERCA2a
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.60 Pain Relevance 0
Expression of the stress signaling molecules MEK1/2, ERK, JNK and p38 MAP kinase, the intracellular Ca2+ regulatory proteins sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2a) and phospholamban, the ER stress proteins BIP (GRP78), pan and phospho-eIF2?
Gene_expression (Expression) of SERCA2a in reticulum associated with stress
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.27 Pain Relevance 0
However, prolonged exposure (18 hrs) of lethal toxin in vivo failed to affect the expression of intracellular Ca2+ regulatory proteins SERCA2a and phospholamban (Fig. 11).
Gene_expression (expression) of SERCA2a
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.61 Pain Relevance 0

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