INT16644

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Context Info
Confidence 0.60
First Reported 1980
Last Reported 2008
Negated 2
Speculated 1
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 6.38
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plg) extracellular space (Plg) extracellular region (Plg)
Anatomy Link Frequency
liver 2
plasma 1
Platelet 1
Plg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 28 98.74 Very High Very High Very High
anesthesia 7 93.68 High High
epidural 5 93.24 High High
Restless leg syndrome 7 92.88 High High
Pain 2 89.64 High High
cva 3 84.88 Quite High
headache 1 83.96 Quite High
cINOD 1 82.72 Quite High
aspirin 1 78.80 Quite High
Regional anesthesia 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 13 99.08 Very High Very High Very High
Cv General 3 Under Development 29 98.74 Very High Very High Very High
Metastasis 1 98.00 Very High Very High Very High
Coronary Artery Disease 10 94.88 High High
Reprotox - General 1 7 94.28 High High
Thrombosis 2 94.24 High High
Necrosis 3 93.08 High High
Increased Venous Pressure Under Development 17 92.76 High High
Infarction 1 90.80 High High
Hemorrhage 4 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the activity of plasminogen (PLG) increased in both groups and the change was more marked in the trial group (p < 0.01).
Positive_regulation (increased) of PLG
1) Confidence 0.60 Published 2008 Journal Phytother Res Section Abstract Doc Link 18688814 Disease Relevance 0.46 Pain Relevance 0.35
The results suggested that B. macrostemi combined with baseline therapy could improve clinical symptoms of UA/NSTEMI patients by decreasing the ox-LDL and PAI-1 levels and enhancing the activity of PLG.
Positive_regulation (enhancing) of PLG associated with angina
2) Confidence 0.41 Published 2008 Journal Phytother Res Section Abstract Doc Link 18688814 Disease Relevance 0.41 Pain Relevance 0.23
In contrast, the activity of plasminogen (PLG) increased in both groups and the change was more marked in the trial group (p < 0.01).
Positive_regulation (increased) of plasminogen
3) Confidence 0.41 Published 2008 Journal Phytother Res Section Abstract Doc Link 18688814 Disease Relevance 0.46 Pain Relevance 0.35
Currently available fibrin-unspecific plasminogen activators such as streptokinase and urokinase are effective thrombolytic agents but do not fulfill all the criteria of an ideal plasminogen activator.
Positive_regulation (activators) of plasminogen
4) Confidence 0.32 Published 1988 Journal Klin. Wochenschr. Section Abstract Doc Link 3279257 Disease Relevance 0.34 Pain Relevance 0
Plasma samples collected from rat liver donors that had received DES showed similar effects on protein concentrations: significant decreases in concentration of plasminogen and antithrombin III were apparent with no significant changes in concentrations of fibrinogen, fibronectin, or albumin.
Positive_regulation (concentration) of plasminogen in liver
5) Confidence 0.26 Published 1985 Journal Blood Section Abstract Doc Link 4016277 Disease Relevance 0 Pain Relevance 0.07
Coagulation analyses furthermore show an increase of the factor VIII activity and the plasminogen levels.
Positive_regulation (increase) of plasminogen
6) Confidence 0.17 Published 1980 Journal MMW Munch Med Wochenschr Section Abstract Doc Link 6767967 Disease Relevance 0.16 Pain Relevance 0.18
Platelet count, prothrombin time, aPTT and plasminogen were unchanged.
Neg (unchanged) Positive_regulation (unchanged) of plasminogen in Platelet
7) Confidence 0.15 Published 1995 Journal Scand J Rehabil Med Section Abstract Doc Link 7569823 Disease Relevance 0.47 Pain Relevance 0.23
The levels of plasma plasminogen, fibrinogen and FDP were also significantly changed in these patients.
Positive_regulation (changed) of plasminogen in plasma
8) Confidence 0.11 Published 1989 Journal Chin. Med. J. Section Abstract Doc Link 2517077 Disease Relevance 0.81 Pain Relevance 0.20
This particular precaution seems to be necessary because low-molecular-weight heparin increases levels of plasminogen activators (t-PA) and therefore has fibrinolytic activity.
Positive_regulation (increases) of plasminogen
9) Confidence 0.05 Published 1989 Journal Reg Anaesth Section Abstract Doc Link 2685921 Disease Relevance 0.59 Pain Relevance 0.84
Lysis of a fibrin clot (fibrinolysis) is achieved by the active enzyme plasmin obtained by activation of the proenzyme plasminogen by plasminogen activators.
Positive_regulation (activation) of plasminogen
10) Confidence 0.05 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.08 Pain Relevance 0
Lysis of a fibrin clot (fibrinolysis) is achieved by the active enzyme plasmin obtained by activation of the proenzyme plasminogen by plasminogen activators.
Positive_regulation (activators) of plasminogen
11) Confidence 0.04 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2409441 Disease Relevance 0.08 Pain Relevance 0
The plasminogen activating inhibitor-1(PAI-1) in Group G and Group G+E was more elevated perioperatively and became higher than that in Group E (P<0.01).
Positive_regulation (elevated) of plasminogen
12) Confidence 0.03 Published 2004 Journal Beijing Da Xue Xue Bao Section Body Doc Link 15303131 Disease Relevance 0 Pain Relevance 0
LMW heparin also exerted an antithrombotic and profibrinolytic effect by significantly increasing both the anti-Xa factor and plasminogen activity without markedly modifying activated partial thromboplastin time (+20%).
Positive_regulation (increasing) of plasminogen
13) Confidence 0.02 Published 1991 Journal Angiology Section Abstract Doc Link 1847026 Disease Relevance 0.44 Pain Relevance 0.31
CPU removes C-terminal lysine residues that act as plasminogen binding sites from partially degraded fibrin, thereby down-regulating plasminogen activation and fibrinolysis.
Positive_regulation (activation) of plasminogen
14) Confidence 0.02 Published 2000 Journal Thromb. Haemost. Section Abstract Doc Link 11019956 Disease Relevance 0.40 Pain Relevance 0.07
The recently described thrombin-activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis by cleaving of the C-terminal lysine residues from fibrin, thereby inhibiting tPA mediated plasminogen activation.
Positive_regulation (activation) of plasminogen
15) Confidence 0.02 Published 2003 Journal Thromb. Haemost. Section Abstract Doc Link 12876631 Disease Relevance 0.64 Pain Relevance 0.45
These procedures activate plasminogen but are without effect on prorenin.
Positive_regulation (activate) of plasminogen
16) Confidence 0.02 Published 1987 Journal Clin Exp Hypertens A Section Abstract Doc Link 3308199 Disease Relevance 0.09 Pain Relevance 0.09
Herein, the molecular evidence documenting that bone metastasis microenvironment survival factors (mainly the paracrine growth hormone-independent, urokinase-type plasminogen activator-mediated increase of IGF-1 and the endocrine production of growth hormone-dependent IGF-1, mainly liver-derived IGF-1 production) produce an epigenetic form of prostate cancer cells that are resistant to proapoptotic therapies is reviewed.
Positive_regulation (increase) of plasminogen in liver associated with reprotox - general 1 and metastasis
17) Confidence 0.01 Published 2006 Journal Expert Opin Investig Drugs Section Abstract Doc Link 16787142 Disease Relevance 0.43 Pain Relevance 0.16
There were no significant changes in glucose metabolism or in haematological factors except for possibly minor increases in factors VII and X, fibrinogen and plasminogen.
Neg (except) Spec (possibly) Positive_regulation (increases) of plasminogen
18) Confidence 0.01 Published 1995 Journal Contraception Section Abstract Doc Link 7750281 Disease Relevance 0.49 Pain Relevance 0.08

General Comments

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