INT166449

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.73
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NR3C1) nucleoplasm (NR3C1) signal transduction (NR3C1)
aging (NR3C1) nucleolus (NR3C1) nucleus (NR3C1)
Anatomy Link Frequency
thymocyte 4
peripheral nerves 2
epithelial cells 2
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 32 97.36 Very High Very High Very High
Inflammation 18 95.08 Very High Very High Very High
peripheral neuropathy 1 92.64 High High
carpal tunnel syndrome 1 91.60 High High
cytokine 40 88.48 High High
Peripheral nerve injury 2 75.00 Quite High
Sciatic nerve 1 67.36 Quite High
agonist 57 34.08 Quite Low
corticosteroid 24 5.00 Very Low Very Low Very Low
antagonist 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 9 99.42 Very High Very High Very High
Occupational Lung Diseases 15 96.90 Very High Very High Very High
INFLAMMATION 18 95.08 Very High Very High Very High
Peripheral Neuropathy 1 92.64 High High
Carpal Tunnel Syndrome 1 91.60 High High
Apoptosis 90 91.24 High High
Asthma 183 86.68 High High
Injury 3 75.00 Quite High
Nervous System Injury 2 75.00 Quite High
Body Weight 4 22.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies have shown that the glucocorticoid receptor (GR) in GCR asthmatics exhibits a lower interaction with activator protein-1 (AP-1), and this effect is accompanied by raised levels of AP-1.[26] Mathieu et al. have shown that overexpression of the GR gene in A549 human lung epithelial cells, using a GR expression vector, resulted in repression of both nuclear factor kappa-B (NF-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of GR in epithelial cells associated with repression and occupational lung diseases
1) Confidence 0.68 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.60 Pain Relevance 0.12
B repression was also observed following overexpression of a GR ligand-binding mutant in the same cell line.
Positive_regulation (overexpression) of Gene_expression (overexpression) of GR associated with repression
2) Confidence 0.49 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.56 Pain Relevance 0.11
B repression to be strictly hormone dependent.[28] These findings suggest that overexpression of the GR in vivo may be a potentially useful approach to gene therapy, especially as a complimentary or alternative treatment for GCR asthmatics.
Positive_regulation (overexpression) of Gene_expression (overexpression) of GR associated with repression and occupational lung diseases
3) Confidence 0.46 Published 2010 Journal Indian Journal of Human Genetics Section Body Doc Link PMC3009420 Disease Relevance 0.57 Pain Relevance 0.11
Schwann cells of the peripheral nerves express glucocorticoid receptors (GR), and glucocorticoids enhance the rate of myelin formation in vitro.
Positive_regulation (enhance) of Gene_expression (express) of GR in peripheral nerves
4) Confidence 0.38 Published 2010 Journal Glia Section Abstract Doc Link 20169622 Disease Relevance 0.56 Pain Relevance 0.26
Lectin treatment for 21 days caused >20% elevation of GCR expression in all thymocyte subpopulations (DN, DP, CD4+ and CD8+).
Positive_regulation (elevation) of Gene_expression (expression) of GCR in thymocyte
5) Confidence 0.07 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0.72 Pain Relevance 0.20
Lectin treatment for 21 days caused >20% elevation of GCR expression in all thymocyte subpopulations (DN, DP, CD4+ and CD8+).
Positive_regulation (caused) of Gene_expression (expression) of GCR in thymocyte
6) Confidence 0.07 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0.72 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox