INT166456

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.72
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Anatomy Link Frequency
brains 4
spinal 2
T cell 2
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 9 100.00 Very High Very High Very High
Arthritis 56 83.00 Quite High
Hyperalgesia 1 76.28 Quite High
Peripheral sensitization 1 75.60 Quite High
Pyramidal cell 4 65.56 Quite High
cytokine 38 60.24 Quite High
Central nervous system 28 22.16 Low Low
Inflammation 51 5.00 Very Low Very Low Very Low
Kinase C 36 5.00 Very Low Very Low Very Low
Hippocampus 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
Disease 210 99.74 Very High Very High Very High
Congenital Anomalies 12 97.92 Very High Very High Very High
Systemic Lupus Erythematosus 1 89.64 High High
Arthritis 59 83.00 Quite High
Immunization 3 82.28 Quite High
Toxicity 4 79.20 Quite High
Hyperalgesia 1 76.28 Quite High
Hypersensitivity 9 64.28 Quite High
Dementia 30 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of peripheral PI3K signaling dose-dependently prevented and reversed pain behaviors and spinal Fos protein expression induced by intraplantar injection of ephrinB1-Fc.
Negative_regulation (Inhibition) of Gene_expression (expression) of PI3K in spinal associated with pain
1) Confidence 0.41 Published 2010 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 20170671 Disease Relevance 0.33 Pain Relevance 0.45
Additionally, although defective T cell differentiation can be detected in newborn PI3K?
Negative_regulation (differentiation) of Gene_expression (detected) of PI3K in T cell
2) Confidence 0.14 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2867834 Disease Relevance 0.50 Pain Relevance 0.13
AD brains also demonstrate reduced expression of the IRS, IRS-associated PI3K, and activated AKT/PKB [82], suggesting downstream abnormalities in insulin/IGF intracellular signalling mechanisms.
Negative_regulation (demonstrate) of Gene_expression (expression) of PI3K in brains associated with congenital anomalies and disease
3) Confidence 0.14 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.45 Pain Relevance 0.03
AD brains also demonstrate reduced expression of the IRS, IRS-associated PI3K, and activated AKT/PKB [82], suggesting downstream abnormalities in insulin/IGF intracellular signalling mechanisms.
Negative_regulation (reduced) of Gene_expression (expression) of PI3K in brains associated with congenital anomalies and disease
4) Confidence 0.14 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.45 Pain Relevance 0.03

General Comments

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