INT166467

Context Info Confidence 0.50 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 8 Disease Relevance 5.50 Pain Relevance 2.04

signal transduction (Tnfrsf11b) extracellular space (Tnfrsf11b) extracellular region (Tnfrsf11b) proteinaceous extracellular matrix (Tnfrsf11b) extracellular matrix organization (Tnfrsf11b)

Anatomy Link Frequency joint 4 chondrocytes 4 Tnfrsf11b (Rattus norvegicus)

Pain Link Frequency Relevance Heat Arthritis 231 99.28 Osteoarthritis 6 97.62 Snapping jaw 9 97.32 psoriasis 57 94.60 cINOD 6 61.52 methotrexate 6 59.60 rheumatoid arthritis 13 58.08 cytokine 6 53.24 Inflammation 27 48.08 Analgesic 1 41.84

Disease Link Frequency Relevance Heat Repression 3 100.00 Hypoxia 12 99.84 Seronegative Spondarthritis 201 99.28 Psoriasis 66 99.08 Osteoarthritis 6 97.62 Osteoporosis 16 97.44 Temporomandibular Joint Syndrome 9 97.32 Endometriosis (extended) 1 94.32 Osteoporotic Fractures 3 90.08 Bone Cancer 18 87.60

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, expression of Opg decreased in hypoxia, and Hif-1alpha played a role, in part, in its regulation.

Negative_regulation (decreased) of Gene_expression (expression) of Opg associated with hypoxia

1) Confidence 0.50 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.74 Pain Relevance 0.27

Here we demonstrate for the first time that hypoxia-inducible factor-1alpha (Hif-1alpha) is activated in mature chondrocytes of temporomandibular joint-osteoarthritis (TMJ-OA) model rat by mechanical overload, and that activated Hif-1 in chondrocytes can induce osteoclastogenesis via repression of osteoprotegerin (Opg) expression.

Negative_regulation (repression) of Gene_expression (expression) of Opg in chondrocytes associated with snapping jaw, hypoxia, repression and osteoarthritis

2) Confidence 0.50 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.78 Pain Relevance 0.35

Here we demonstrate for the first time that hypoxia-inducible factor-1alpha (Hif-1alpha) is activated in mature chondrocytes of temporomandibular joint-osteoarthritis (TMJ-OA) model rat by mechanical overload, and that activated Hif-1 in chondrocytes can induce osteoclastogenesis via repression of osteoprotegerin (Opg) expression.

Negative_regulation (repression) of Gene_expression (expression) of osteoprotegerin in chondrocytes associated with snapping jaw, hypoxia, repression and osteoarthritis

3) Confidence 0.36 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.78 Pain Relevance 0.35

Although 1,25(OH)2D has been demonstrated in in-vitro studies to increase RANKL expression [5] and reduce the OPG expression [9], supplementation with vitamin D in our study did not significantly affect their serum levels.

Negative_regulation (reduce) of Gene_expression (expression) of OPG

4) Confidence 0.34 Published 2010 Journal Nutr J Section Body Doc Link PMC2818614 Disease Relevance 0.17 Pain Relevance 0.03

This is attributed to increased RANKL production and impaired osteoprotegerin synthesis.

Negative_regulation (impaired) of Gene_expression (synthesis) of osteoprotegerin

5) Confidence 0.28 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20840284 Disease Relevance 0.47 Pain Relevance 0

For example, it has been reported that OPG expression is limited to endothelial cells below the synovial membrane within the psoriatic joint [12]; in contrast, we did not identify reduced circulating OPG concentrations in patients with PsA or a relation between these concentrations and patterns of bone remodeling.

Negative_regulation (limited) of Gene_expression (expression) of OPG in joint associated with psoriasis and arthritis

6) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 0.52 Pain Relevance 0.17

No overall difference was noted in RANKL or OPG concentrations between the groups of patients with erosive and nonerosive PsA (Figure 1g and 1h).

Negative_regulation (noted) of Gene_expression (concentrations) of OPG associated with arthritis

7) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 1.47 Pain Relevance 0.69

For example, it has been reported that OPG expression is limited to endothelial cells below the synovial membrane within the psoriatic joint [12]; in contrast, we did not identify reduced circulating OPG concentrations in patients with PsA or a relation between these concentrations and patterns of bone remodeling.

Negative_regulation (reduced) of Gene_expression (concentrations) of OPG in joint associated with psoriasis and arthritis

8) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945067 Disease Relevance 0.57 Pain Relevance 0.18

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