INT166482

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Context Info
Confidence 0.15
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.51
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AKR1A1) oxidoreductase activity (AKR1A1)
Anatomy Link Frequency
blood 1
AKR1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 23 100.00 Very High Very High Very High
acular 13 94.48 High High
Inflammation 10 76.52 Quite High
palliative 1 73.92 Quite High
Opioid 1 70.36 Quite High
antagonist 6 68.16 Quite High
opioid receptor 1 67.72 Quite High
Analgesic 3 65.36 Quite High
Eae 7 57.48 Quite High
headache 70 50.00 Quite Low
Disease Link Frequency Relevance Heat
Poisoning 10 99.28 Very High Very High Very High
Toxicity 18 94.76 High High
Acidosis 2 93.28 High High
Renal Insufficiency 3 91.32 High High
Lactic Acidosis 21 90.36 High High
Stress 9 85.00 Quite High
Pre-eclampsia 33 83.04 Quite High
Vomiting 4 77.12 Quite High
INFLAMMATION 11 76.52 Quite High
Weight Gain 1 76.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Formation of M4 and M5 was catalyzed by NADPH-dependent hepatic cytosolic enzymes, which were identified using selective chemical inhibitors (10 and 100 microM) for aldo-keto reductase (AKR) isoforms, short-chain dehydrogenase/reductase including carbonyl reductase, alcohol dehydrogenase, and quinone oxidoreductase.
Negative_regulation (inhibitors) of alcohol dehydrogenase associated with alcohol
1) Confidence 0.15 Published 2010 Journal Drug Metab. Dispos. Section Abstract Doc Link 20173089 Disease Relevance 0.15 Pain Relevance 0.26
Even if our patient had had severe toxic alcohol poisoning, the treatment would have included alcohol dehydrogenase inhibition, which was already effected by the presence of ethanol, and hemodialysis, which was already planned to treat his severe metformin toxicity.


Negative_regulation (inhibition) of alcohol dehydrogenase associated with toxicity, poisoning and alcohol
2) Confidence 0.11 Published 2008 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2672258 Disease Relevance 1.39 Pain Relevance 0.17
The low levels of Ang-(1–7) and ACE2 in the RUPP model may represent an inhibition of the vasodilator arm of the renin-angiotensin system associated with factors generated by the reduced placental blood flow (sFlt-1, TNF-?
Negative_regulation (inhibition) of arm in blood
3) Confidence 0.05 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.08 Pain Relevance 0
4-methyl pyrazole (Sigma-Aldrich, St Louis, MO, USA) prevents the conversion of ethanol to acetaldehyde by inhibiting alcohol dehydrogenase or CYP2E1 [34], [35].
Negative_regulation (inhibiting) of alcohol dehydrogenase associated with alcohol
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013144 Disease Relevance 0.08 Pain Relevance 0.59
Garlic has been demonstrated to inhibit the alkaline phosphatase [161], papain, and alcohol dehydrogenase [169].
Negative_regulation (inhibit) of alcohol dehydrogenase associated with alcohol
5) Confidence 0.01 Published 2002 Journal Nutr J Section Body Doc Link PMC139960 Disease Relevance 0.82 Pain Relevance 0.05

General Comments

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