INT166490

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Context Info
Confidence 0.80
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 0.61
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Msn) nucleolus (Msn) plasma membrane (Msn)
cytoskeleton (Msn) nucleus (Msn) protein binding, bridging (Msn)
Anatomy Link Frequency
neuronal 1
shell 1
neck 1
neurons 1
muscle 1
Msn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pyramidal cell 336 100.00 Very High Very High Very High
projection neuron 95 100.00 Very High Very High Very High
Enkephalin 60 100.00 Very High Very High Very High
Acupuncture 8 100.00 Very High Very High Very High
Nucleus accumbens 296 99.48 Very High Very High Very High
potassium channel 3 99.12 Very High Very High Very High
Neuronal excitability 2 97.76 Very High Very High Very High
repetitive firing 2 96.72 Very High Very High Very High
Dopamine 138 94.32 High High
Pain 4 92.80 High High
Disease Link Frequency Relevance Heat
Pain 4 92.80 High High
Adhesions 1 91.12 High High
Myofascial Pain Syndromes 8 89.96 High High
Apoptosis 1 80.00 Quite High
Parkinson's Disease 12 67.52 Quite High
Pulmonary Fibrosis 3 55.32 Quite High
Wound Healing 1 53.72 Quite High
Asthma 5 49.80 Quite Low
Cancer 13 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DISCUSSION: The effectiveness of MSN release for MPS is superior to that of acupuncture needling treatment or self neck-stretching exercises alone.
Localization (release) of MSN in superior
1) Confidence 0.80 Published 2010 Journal Clin J Pain Section Body Doc Link 20173440 Disease Relevance 0 Pain Relevance 0
The MSN release is also safe, without severe side effects in treatment of MPS.


Localization (release) of MSN
2) Confidence 0.80 Published 2010 Journal Clin J Pain Section Body Doc Link 20173440 Disease Relevance 0 Pain Relevance 0
In contrast, similar stimulation intensities showed that DA depletion enhanced and prolonged synaptic potentials in ENK+ MSN (Figures 6D–F) even more than in control conditions, resulting in larger corticostriatal responses to any stimulus in indirect pathway neurons (Figures 6D–F), as though inhibition was less capable to control intrinsic excitability in ENK+ MSNs (Taverna et al., 2008; Tecuapetla et al., 2009).
Localization (excitability) of MSN in neurons associated with dopamine, projection neuron and enkephalin
3) Confidence 0.73 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893005 Disease Relevance 0.07 Pain Relevance 0.72
We carried out this study to investigate the effectiveness of miniscalpel-needle (MSN) release and acupuncture needling and self neck-stretching exercises on myofascial TrPs of the upper trapezius muscle.
Localization (release) of MSN in muscle associated with acupuncture
4) Confidence 0.70 Published 2010 Journal Clin J Pain Section Abstract Doc Link 20173440 Disease Relevance 0.26 Pain Relevance 0.38
METHODS: Eighty-three TrPs in 43 patients with MPS were treated and randomly assigned to 3 groups: group 1 received MSN release in conjunction with self neck-stretching exercises; group 2 received acupuncture needling treatment and performed self neck-stretching exercises; and group 3, the control group, was assigned self neck-stretching exercises only.
Localization (release) of MSN in neck
5) Confidence 0.70 Published 2010 Journal Clin J Pain Section Body Doc Link 20173440 Disease Relevance 0 Pain Relevance 0
Our principal finding is that the dendritic arborizations of MSN in both the Acb shell and core subregions are preferentially oriented, i.e., they are flattened in at least one of the 3D-planes.
Localization (arborizations) of MSN in shell associated with nucleus accumbens and pyramidal cell
6) Confidence 0.64 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.60
Spatial organization and orientation of dendritic arborizations of MSN
Localization (arborizations) of MSN associated with pyramidal cell
7) Confidence 0.64 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.29
We hypothesized that this increase in MSN intrinsic excitability could involve A-type potassium channels, which control neuronal excitability and repetitive firing [25].
Localization (excitability) of MSN in neuronal associated with neuronal excitability, repetitive firing and potassium channel
8) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2733153 Disease Relevance 0 Pain Relevance 0.30
Moesin and PIPTN enable the cytosolic RhoA/Rho-GDI complex to partially unfold and reveal hydrophobic regions which are able to attach to cell membrane surfaces, and in doing so, release Rho-GTP proteins – active in cytoskeletal reorganization [28-33].
Localization (release) of Moesin
9) Confidence 0.47 Published 2007 Journal Respir Res Section Body Doc Link PMC1876226 Disease Relevance 0.28 Pain Relevance 0.03

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