INT1665

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Context Info
Confidence 0.68
First Reported 1979
Last Reported 2010
Negated 3
Speculated 11
Reported most in Abstract
Documents 270
Total Number 284
Disease Relevance 186.63
Pain Relevance 229.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
neurons 28
PAG 27
lateral 10
midbrain 8
LRF 7
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 2035 100.00 Very High Very High Very High
Morphine 772 100.00 Very High Very High Very High
Pain 681 100.00 Very High Very High Very High
GABAergic 470 100.00 Very High Very High Very High
Periaqueductal grey 373 100.00 Very High Very High Very High
opioid receptor 345 100.00 Very High Very High Very High
Rostral ventromedial medulla 250 100.00 Very High Very High Very High
Raphe magnus 239 100.00 Very High Very High Very High
Antinociceptive 207 100.00 Very High Very High Very High
analgesia 179 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2974 100.00 Very High Very High Very High
Pain 602 100.00 Very High Very High Very High
Nociception 403 100.00 Very High Very High Very High
Neuropathic Pain 242 99.98 Very High Very High Very High
Shock 9 99.98 Very High Very High Very High
Bradycardia 34 99.92 Very High Very High Very High
Overactive Bladder 4 99.92 Very High Very High Very High
Diabetes Mellitus 30 99.84 Very High Very High Very High
Generalized Anxiety Disorder 308 99.72 Very High Very High Very High
Aids-related Complex 2 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Connectivity analyses showed that asthma-specific down-regulation of the insular cortex during dyspnea and pain was moderated by increased PAG activity.
Positive_regulation (increased) of PAG in insular cortex
1) Confidence 0.68 Published 2009 Journal Am. J. Respir. Crit. Care Med. Section Body Doc Link 19483110 Disease Relevance 0 Pain Relevance 0
The degree of suppression of unit responses increased with graded increases in PAG or LRF stimulation intensity.
Positive_regulation (increases) of PAG in LRF associated with central grey
2) Confidence 0.54 Published 1986 Journal Brain Res. Section Abstract Doc Link 3756519 Disease Relevance 0.68 Pain Relevance 0.53
This shows that spores rapidly germinate at the site of injection and quickly become metabolically active, and that the pag promoter is induced; these results are similar to those obtained in tissue culture models [24,25], but unlike previous studies that suggested that germination occurs in the draining lymph nodes [7,10].
Positive_regulation (induced) of pag in lymph nodes associated with urological neuroanatomy
3) Confidence 0.53 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1885272 Disease Relevance 0.56 Pain Relevance 0
The inhibition was exclusively of central origin because inhibition of BVB by stimulation of the PAG was unchanged after transection of the spinal cord at the C1 level.
Positive_regulation (stimulation) of PAG in PAG associated with urological neuroanatomy, bradycardia and spinal cord
4) Confidence 0.49 Published 1993 Journal J. Neurophysiol. Section Abstract Doc Link 7907131 Disease Relevance 1.22 Pain Relevance 0.33
The results showed that the administration of N-methylnaltrexone directly into the PAG antagonized morphine's effects on natural killer cell activity, which indicate that activation of opioid receptors within the PAG are required for morphine to alter natural killer cell activity.
Positive_regulation (activation) of PAG in natural killer cell associated with opioid receptor, central grey and morphine
5) Confidence 0.47 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8667220 Disease Relevance 0.79 Pain Relevance 1.52
These results indicate that stimulation in NRM and PAG not only inhibits the responses of noci neurons but also those of nonnoci neurons.
Positive_regulation (stimulation) of PAG in neurons associated with raphe magnus and central grey
6) Confidence 0.40 Published 1983 Journal J. Neurophysiol. Section Abstract Doc Link 6854363 Disease Relevance 0.76 Pain Relevance 0.67
Therefore, the ME or CE are unlikely to be intermediary stations for depression of the TFR evoked by stimulating the PAG, but the PAG may be a relay station for the effects of stimulating the ME or CE.
Positive_regulation (stimulating) of PAG in intermediary associated with depression and central grey
7) Confidence 0.40 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11226714 Disease Relevance 0.87 Pain Relevance 1.04
This perceptual difference was mirrored by reduced insular cortex activity, but increased activity in the periaqueductal gray (PAG) in patients during both increased dyspnea and pain.
Positive_regulation (increased) of PAG in insular cortex
8) Confidence 0.40 Published 2009 Journal Am. J. Respir. Crit. Care Med. Section Body Doc Link 19483110 Disease Relevance 0.12 Pain Relevance 0
Thus PGC does not appear to participate in tonic descending pain inhibition (as PAG appears to do) nor is its functional integrity necessary for PAG ME analgesia (though PAG is necessary for PGC analgesia).
Positive_regulation (necessary) of PAG associated with pain, urological neuroanatomy, enkephalin and analgesia
9) Confidence 0.39 Published 1994 Journal Int. J. Neurosci. Section Abstract Doc Link 7928102 Disease Relevance 0.81 Pain Relevance 1.74
Activation of mu-opioid receptors in VMM and PAG also modifies processes in addition to nociceptive transmission.
Positive_regulation (Activation) of PAG in VMM associated with nociception, medulla, mu opioid receptor and central grey
10) Confidence 0.39 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 16105951 Disease Relevance 1.01 Pain Relevance 0.97
These neurons were most frequently seen in the ventrolateral and ventral parts of the medial PAG subdivisions at all rostrocaudal levels of PAG.
Positive_regulation (levels) of PAG in ventral associated with central grey
11) Confidence 0.39 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 1704115 Disease Relevance 0.45 Pain Relevance 0.63
Since morphine has no effect on histamine catabolism, these results suggest that morphine increases histamine release in the rat PAG, a site where morphine and histamine are known to have analgesic action.
Positive_regulation (increases) of PAG associated with analgesic, urological neuroanatomy and morphine
12) Confidence 0.39 Published 1992 Journal Brain Res. Section Abstract Doc Link 1611509 Disease Relevance 0.36 Pain Relevance 1.29
Metamizol (140 mg/kg) i.v. increased the activity of neurones in the PAG and reduced that of neurones in the substantia nigra.
Positive_regulation (increased) of PAG in substantia nigra associated with substantia nigra and urological neuroanatomy
13) Confidence 0.39 Published 1986 Journal Pain Section Abstract Doc Link 3808743 Disease Relevance 0.33 Pain Relevance 0.81
In control rats, stimulation of the PAG (400 ms at 70/s) prior to each sciatic nerve pulse reorganized the late activity peaks of the nociceptive neurons: a single late peak occurred during the 280 to 400 ms poststimulus interval, indicating suppression of pain by electroanalgesia.
Positive_regulation (stimulation) of PAG in neurons associated with nociception, pain, urological neuroanatomy and sciatic nerve
14) Confidence 0.39 Published 1985 Journal Exp. Neurol. Section Abstract Doc Link 3872807 Disease Relevance 0.95 Pain Relevance 0.88
Stimulation of the PAG reorganized the late peaks but only if the sciatic nerve stimulation was not increased.
Positive_regulation (Stimulation) of PAG in PAG associated with urological neuroanatomy and sciatic nerve
15) Confidence 0.39 Published 1985 Journal Exp. Neurol. Section Abstract Doc Link 3872807 Disease Relevance 0.93 Pain Relevance 0.82
The analgesic effect of electrical stimulation of the periaqueductal gray matter (PAG) was studied in 4 strains of mice: C57BL/6By (C57), BALB/cBy (BALB), CXBH, and CXBK.
Positive_regulation (stimulation) of PAG in PAG associated with analgesic, urological neuroanatomy, sprains and strains and central grey
16) Confidence 0.39 Published 1990 Journal Brain Res. Section Abstract Doc Link 2154297 Disease Relevance 0.47 Pain Relevance 0.89
The analgesic effect of electrical stimulation of the periaqueductal gray matter (PAG) was studied in mice selectively bred for high and low stress-induced analgesia (HA and LA lines, respectively).
Positive_regulation (stimulation) of PAG in gray matter associated with stress, analgesic, urological neuroanatomy, central grey and analgesia
17) Confidence 0.39 Published 1989 Journal Brain Res. Section Abstract Doc Link 2743148 Disease Relevance 0.37 Pain Relevance 0.81
Stimulation of PAG produces vocalization and its lesion produces mutism.
Positive_regulation (Stimulation) of PAG associated with mutism and central grey
18) Confidence 0.39 Published 1995 Journal Prog. Neurobiol. Section Abstract Doc Link 8545545 Disease Relevance 2.42 Pain Relevance 1.20
Overall, the results provide novel evidence of descending control into motor control centres, and provide the basis for future studies into the role of the PAG in regulating motor activity in different behavioural states and in chronic pain.
Positive_regulation (role) of PAG associated with lasting pain and periaqueductal grey
19) Confidence 0.39 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19453624 Disease Relevance 0.49 Pain Relevance 0.48
We suggest that the activation of the vlPAG GABA circuit prevents the animal from entering into REM sleep thereby enabling it to maintain the proper posture and vigilance required for foraging and feeding.
Positive_regulation (activation) of vlPAG associated with gaba
20) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0 Pain Relevance 0.23

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