INT16651

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Context Info
Confidence 0.68
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.72
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SEMA6A) plasma membrane (SEMA6A) cytoskeleton organization (SEMA6A)
Anatomy Link Frequency
appendages 1
colon 1
median eminence 1
microglia 1
interneurons 1
SEMA6A (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 3 100.00 Very High Very High Very High
noradrenaline 12 99.98 Very High Very High Very High
Dopamine 10 99.98 Very High Very High Very High
Opioid 3 97.84 Very High Very High Very High
antagonist 3 93.84 High High
Inflammation 42 91.56 High High
Multiple sclerosis 6 90.48 High High
narcan 1 86.76 High High
fibrosis 5 85.72 High High
agonist 4 82.36 Quite High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 1 99.98 Very High Very High Very High
INFLAMMATION 42 91.56 High High
Neurodegenerative Disease 1 90.56 High High
Demyelinating Disease 6 90.48 High High
Brain Disease 3 88.92 High High
Disease 13 86.64 High High
Cystic Fibrosis 4 86.00 High High
Motor Neuron Diseases 1 84.24 Quite High
Shock 1 77.20 Quite High
Schizophrenia 5 74.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that GHB increases dopamine release via specific receptors that may modulate the activity of opioid interneurons.
Localization (release) of via in interneurons associated with dopamine and opioid
1) Confidence 0.68 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1847191 Disease Relevance 0 Pain Relevance 0.71
Since noradrenergic axon terminals in the median eminence do not make synaptic contact and the released noradrenaline does not modulate its own release via alpha2-adrenoceptors, it is an interesting anatomical arrangement: the modulatory alpha2-adrenoceptors are located exclusively on the terminals of the hormone-containing neurons.
Localization (release) of via in median eminence associated with noradrenaline
2) Confidence 0.68 Published 1985 Journal Neuroscience Section Abstract Doc Link 3005913 Disease Relevance 0.08 Pain Relevance 0.39
In conclusion, noradrenaline release in human right atrial appendages is inhibited via 5-HT receptors which are located on the noradrenergic axon terminals.
Localization (release) of via in appendages associated with noradrenaline
3) Confidence 0.68 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.32
Activation of ion secretion via proteinase-activated receptor-2 in human colon.
Localization (secretion) of via in colon
4) Confidence 0.68 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 11804840 Disease Relevance 0.32 Pain Relevance 0.23
induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner.
Localization (release) of via in microglia associated with glutamate and drug induced neurotoxicity
5) Confidence 0.10 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 1.32 Pain Relevance 0.38

General Comments

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