INT16654

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Context Info
Confidence 0.46
First Reported 1986
Last Reported 2011
Negated 3
Speculated 5
Reported most in Abstract
Documents 138
Total Number 143
Disease Relevance 58.96
Pain Relevance 75.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Insrr)
Anatomy Link Frequency
DRG 6
neurons 5
spinal cord 4
brain 4
embryonic kidney 3
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 488 100.00 Very High Very High Very High
agonist 361 100.00 Very High Very High Very High
nMDA receptor 318 100.00 Very High Very High Very High
antagonist 288 100.00 Very High Very High Very High
Dopamine 264 100.00 Very High Very High Very High
gABA 234 100.00 Very High Very High Very High
Opioid 188 100.00 Very High Very High Very High
cytokine 149 100.00 Very High Very High Very High
opioid receptor 143 100.00 Very High Very High Very High
Analgesic 121 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 252 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 47 100.00 Very High Very High Very High
Congenital Anomalies 108 99.92 Very High Very High Very High
Hyperalgesia 203 99.88 Very High Very High Very High
Cancer 1182 99.84 Very High Very High Very High
Gliosis 3 99.48 Very High Very High Very High
Targeted Disruption 1236 99.44 Very High Very High Very High
Nervous System Injury 144 99.44 Very High Very High Very High
Coronary Heart Disease 14 99.30 Very High Very High Very High
Injury 94 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RATIONALE: Neuroactive steroids represent a novel class of potential therapeutic agents (epilepsy, anxiety, migraine, drug dependence) thought to act through positive allosteric modulation of the GABA(A) receptor.
Gene_expression (modulation) of ) receptor associated with drug dependence, epilepsy, addiction, gaba, migraine and anxiety disorder
1) Confidence 0.46 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10928304 Disease Relevance 0.56 Pain Relevance 0.24
Pretreatment with selective serotonin reuptake inhibitor, fluoxetine (5 mg/kg, i.p.), 5-HT releaser, fenfluramine (10 mg/kg, i.p.), 5-HT(1A) receptor agonist, 8-OH-DPAT (0.3 mg/kg, s.c.), 5-HT1B/1C receptor agonist, TFMPP (3 mg/kg, i.p.), 5-HT2A/1C receptor agonist, DOI (1.5 mg/kg, s.c.) and 5-HT3 agonist, 2-methylserotonin (5 mg/kg, i.p.) potentiated the catalepsy induced by exogenous administration of 3alpha,5alpha-THP.
Gene_expression (agonist) of receptor associated with catalepsy, agonist, ssri and fluoxetine
2) Confidence 0.45 Published 2001 Journal Brain Res. Section Abstract Doc Link 11292445 Disease Relevance 0.40 Pain Relevance 0.45
Pretreatment with selective serotonin reuptake inhibitor, fluoxetine (5 mg/kg, i.p.), 5-HT releaser, fenfluramine (10 mg/kg, i.p.), 5-HT(1A) receptor agonist, 8-OH-DPAT (0.3 mg/kg, s.c.), 5-HT1B/1C receptor agonist, TFMPP (3 mg/kg, i.p.), 5-HT2A/1C receptor agonist, DOI (1.5 mg/kg, s.c.) and 5-HT3 agonist, 2-methylserotonin (5 mg/kg, i.p.) potentiated the catalepsy induced by exogenous administration of 3alpha,5alpha-THP.
Gene_expression (agonist) of receptor associated with catalepsy, agonist, ssri and fluoxetine
3) Confidence 0.45 Published 2001 Journal Brain Res. Section Abstract Doc Link 11292445 Disease Relevance 0.40 Pain Relevance 0.48
Both noncompetitively inhibit NMDA receptors, yet there is little evidence that these drugs affect GABA(A) receptors, the primary target of most anesthetics. alpha6beta2/3delta receptors are subtypes of the GABA(A) receptor family and are abundantly expressed in granular neurons within the adult cerebellum.
Gene_expression (expressed) of ) receptor in cerebellum associated with gaba and nmda receptor
4) Confidence 0.42 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18480294 Disease Relevance 0.26 Pain Relevance 0.68
METHODS: Potentiation of the GABA(A) receptor by halothane, sevoflurane, isoflurane, and methoxyflurane was studied at six temperatures in the range 10-37 degrees C using the whole-cell patch-clamp technique and mouse fibroblast cells stably transfected with defined GABA(A) receptor subunits.
Gene_expression (transfected) of ) receptor in fibroblast
5) Confidence 0.32 Published 1999 Journal Anesthesiology Section Body Doc Link 9952156 Disease Relevance 0 Pain Relevance 0
METHODS: Potentiation of the GABA(A) receptor by halothane, sevoflurane, isoflurane, and methoxyflurane was studied at six temperatures in the range 10-37 degrees C using the whole-cell patch-clamp technique and mouse fibroblast cells stably transfected with defined GABA(A) receptor subunits.
Gene_expression (transfected) of ) receptor in fibroblast
6) Confidence 0.32 Published 1999 Journal Anesthesiology Section Body Doc Link 9952156 Disease Relevance 0 Pain Relevance 0
Additionally, normally non-noxious palpation of the bone with cancer induced behaviors indicative of pain, the internalization of the substance P receptor, and c-Fos expression in lamina I neurons.
Gene_expression (expression) of receptor in lamina associated with pain, cancer and substance p
7) Confidence 0.29 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10594070 Disease Relevance 1.33 Pain Relevance 0.89
METHODS: Using intravital microscopy we examined the ocular inflammatory response after the onset of arthritis in mice that overexpressed the T cell receptor (TCR) specific for a dominant arthritogenic epitope of cartilage proteoglycan [TCR-Tg (transgenic) mice] or BALB/c controls.
Gene_expression (overexpressed) of receptor in T cell
8) Confidence 0.26 Published 2008 Journal Ophthalmic Res. Section Body Doc Link 18421237 Disease Relevance 0.19 Pain Relevance 0
The mu and kappa opioid receptor sequences had no SNPs.
Neg (no) Gene_expression (had) of receptor associated with kappa opioid receptor
9) Confidence 0.21 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11427338 Disease Relevance 0.28 Pain Relevance 0.80
This finding suggests that antagonist-induced opiate receptor upregulation does not require the synthesis of new receptor molecules.
Gene_expression (synthesis) of receptor associated with antagonist and opiate
10) Confidence 0.21 Published 1986 Journal Brain Res. Section Abstract Doc Link 3006869 Disease Relevance 0.14 Pain Relevance 0.72
In summary, a 99mTc-labeled sigma receptor imaging agent, [99mTc]2, has demonstrated the feasibility of using a 99mTc-labeled agent for imaging sigma receptor expression in tumor cells.
Gene_expression (expression) of receptor associated with cancer and imagery
11) Confidence 0.19 Published 2001 Journal Nucl. Med. Biol. Section Abstract Doc Link 11518647 Disease Relevance 0.80 Pain Relevance 0.25
Although the mu-selective opioid receptor agonist [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin (DAMGO) (0.1 and 0.3 ng, i.st.) or the kappa-selective opioid agonist dynorphin A-(1-13) (0.1 and 0.3 mu g, i.st.) did not produce any significant effects on behavior, these peptides had an inhibitory effect on the apomorphine (0.5 mg/kg, s.c.)
Gene_expression (produce) of receptor associated with mu agonist, dynorphin, agonist, enkephalin and opioid receptor
12) Confidence 0.16 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8750728 Disease Relevance 0 Pain Relevance 0.68
Pregnenolone is then metabolized to progesterone, an activator of progesterone receptor, and further metabolized to produce allopregnanolone and 3alpha,21-dihydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THDOC), positive allosteric modulators and activators of the GABA(A) receptor.
Gene_expression (produce) of ) receptor associated with gaba
13) Confidence 0.13 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19403993 Disease Relevance 0.65 Pain Relevance 0.64
These findings provide the first electrical and molecular characterization of the GnRH phenotype and demonstrate a novel pattern of late postnatal reorganization of native GABA(A) receptor gene expression and signalling in the GnRH neuronal population.
Gene_expression (expression) of ) receptor in neuronal associated with gaba
14) Confidence 0.11 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11029619 Disease Relevance 0 Pain Relevance 0.29
In ICR mice, i.c.v. heroin receptor selectivity matched that of i.c.v.
Gene_expression (selectivity) of receptor
15) Confidence 0.10 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1847196 Disease Relevance 0 Pain Relevance 1.72
Gene disruption of the kinin B(2) receptor did not interfere with CFA-induced hyperalgesia, but ablation of the gene of the B(1) receptor reduced the hyperalgesia in both ipsilateral (48+/-13%, at 12 h) and contralateral (91+/-22%, at 12 h) paws.
Gene_expression (ablation) of receptor associated with hyperalgesia
16) Confidence 0.09 Published 2001 Journal Neuropharmacology Section Abstract Doc Link 11747905 Disease Relevance 0.89 Pain Relevance 0.44
Antagonistic properties of buprenorphine for epsilon- and micro -opioid receptors were characterized in beta-endorphin- and [d-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO)-induced antinociception, respectively, with the tail-flick test in male ICR mice. epsilon-Opioid receptor agonist beta-endorphin (0.1-1 micro g), micro -opioid receptor agonist DAMGO (0.5-20 ng), or buprenorphine (0.1-20 micro g) administered i.c.v. dose dependently produced antinociception.
Gene_expression (produced) of receptor in tail associated with antinociception, agonist, tail-flick, enkephalin, opioid receptor and buprenorphine
17) Confidence 0.09 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721333 Disease Relevance 0 Pain Relevance 1.45
Disruption of the type 1 inositol 1,4,5-trisphosphate receptor gene suppresses the morphine-induced antinociception in the mouse.
Gene_expression (Disruption) of receptor associated with antinociception, analgesic and morphine
18) Confidence 0.08 Published 2003 Journal Neurosci. Lett. Section Title Doc Link 12972155 Disease Relevance 0 Pain Relevance 0.95
In contrast, the expression of micro -opioid receptor was not affected after repeated treatment with (-)U-50,488H.
Gene_expression (expression) of receptor associated with opioid receptor
19) Confidence 0.08 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622150 Disease Relevance 0 Pain Relevance 0.79
Pharmacological approaches that increase functional delta receptor expression may reveal a novel target for analgesic therapy.
Gene_expression (expression) of receptor associated with analgesic
20) Confidence 0.07 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16135785 Disease Relevance 0.07 Pain Relevance 0.27

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