INT16656

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.62
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
Anatomy Link Frequency
bile 4
NG108-15 2
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Delta opioid receptors 2 100.00 Very High Very High Very High
Bioavailability 1 99.98 Very High Very High Very High
Enkephalin 2 99.40 Very High Very High Very High
MU agonist 1 98.88 Very High Very High Very High
Bile 6 98.54 Very High Very High Very High
Somatostatin 5 97.22 Very High Very High Very High
opioid receptor 4 96.08 Very High Very High Very High
agonist 6 95.36 Very High Very High Very High
tetrodotoxin 2 93.56 High High
Potency 1 92.00 High High
Disease Link Frequency Relevance Heat
Van Bogaert's Disease 4 99.92 Very High Very High Very High
Breast Cancer 1 99.84 Very High Very High Very High
Cancer 10 98.88 Very High Very High Very High
Disease 11 97.96 Very High Very High Very High
Glioma 2 97.96 Very High Very High Very High
Neuroblastoma 2 97.78 Very High Very High Very High
Esophageal Cancer 1 95.68 Very High Very High Very High
Pancreatic Cancer 1 93.40 High High
Migraine Disorders 1 91.60 High High
Lung Cancer 1 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Somatostatin belongs to a group of regulatory peptides that antagonize the action of endogenous steroid hormones, and decreasing their bioavailability decreases the rate of synthesis of delta-aminolevulinate synthase, alpha-aminolevunilic acid (ALA), and polypeptides.
Negative_regulation (decreases) of Gene_expression (synthesis) of delta associated with somatostatin and bioavailability
1) Confidence 0.57 Published 1997 Journal Ther Apher Section Abstract Doc Link 10225763 Disease Relevance 0.23 Pain Relevance 0.36
Expression in other layers and expression of CaMKII-gamma and delta were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (Expression) of delta
2) Confidence 0.42 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9482799 Disease Relevance 0 Pain Relevance 0.16
Expression in other layers and expression of CaMKII-gamma and delta were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (expression) of delta
3) Confidence 0.42 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9482799 Disease Relevance 0 Pain Relevance 0.16
Chronic treatment of neuroblastoma x glioma NG108-15 hybrid cells with the opioid agonist D-Ala,2 D-Leu5-enkephalin (DADLE) induces a homologous desensitization of the delta opioid receptors present in these cells.
Negative_regulation (desensitization) of Gene_expression (present) of delta in NG108-15 associated with neuroblastoma, mu agonist, delta opioid receptors, enkephalin and glioma
4) Confidence 0.41 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1847209 Disease Relevance 0.42 Pain Relevance 0.56
Selection for delta-receptors was reduced by z(eff) and correlated with e-z(eff).
Negative_regulation (reduced) of Gene_expression (Selection) of delta
5) Confidence 0.41 Published 1986 Journal Biochemistry Section Abstract Doc Link 3024707 Disease Relevance 0 Pain Relevance 0.24
Five inborn errors with consequences for bile acid biosynthesis have been described: 7-dehydrocholesterol 7-reductase deficiency, 3 beta-hydroxysteroid delta 5-oxidoreductase/isomerase deficiency, 3-oxo-delta 4-steroid 5 beta-reductase deficiency, sterol 27-hydroxylase deficiency (cerebrotendinous xanthomatosis), and peroxisomal disease(s) with absence of peroxisomes.
Negative_regulation (deficiency) of Gene_expression (deficiency) of delta in bile associated with bile, van bogaert's disease and disease
6) Confidence 0.41 Published 1994 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 7824882 Disease Relevance 0.38 Pain Relevance 0.18
Five inborn errors with consequences for bile acid biosynthesis have been described: 7-dehydrocholesterol 7-reductase deficiency, 3 beta-hydroxysteroid delta 5-oxidoreductase/isomerase deficiency, 3-oxo-delta 4-steroid 5 beta-reductase deficiency, sterol 27-hydroxylase deficiency (cerebrotendinous xanthomatosis), and peroxisomal disease(s) with absence of peroxisomes.
Negative_regulation (deficiency) of Gene_expression (deficiency) of delta in bile associated with bile, van bogaert's disease and disease
7) Confidence 0.41 Published 1994 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 7824882 Disease Relevance 0.39 Pain Relevance 0.19
It also has been shown to decrease AP-2 and YY-1 transcription factor expression in breast cancer cells and tumors [320].
Negative_regulation (decrease) of Gene_expression (expression) of YY-1 transcription factor associated with cancer and breast cancer
8) Confidence 0.12 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 1.20 Pain Relevance 0.27

General Comments

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