INT166574

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 3.52
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Plaur) plasma membrane (Plaur) enzyme binding (Plaur)
kinase activity (Plaur)
Anatomy Link Frequency
extracellular matrix 1
Plaur (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 11 99.68 Very High Very High Very High
Inflammation 83 70.00 Quite High
cytokine 4 54.72 Quite High
Osteoarthritis 2 50.00 Quite Low
Inflammatory response 10 33.56 Quite Low
substance P 14 5.00 Very Low Very Low Very Low
Inflammatory stimuli 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 111 99.68 Very High Very High Very High
Diabetes Mellitus 38 99.56 Very High Very High Very High
Injury 130 99.32 Very High Very High Very High
Cancer 188 95.40 Very High Very High Very High
Wound Healing 18 94.80 High High
Adhesions 41 90.84 High High
Metastasis 20 87.00 High High
Colon Cancer 51 81.68 Quite High
Myocardial Infarction 1 81.12 Quite High
INFLAMMATION 101 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular we demonstrated that transient gene transfer of HOXA3 to skin wounds of diabetic mice resulted in the upregulation of target genes, such as Plaur, Mmp14, and Cdc42, that are involved in extracellular matrix remodeling and cell migration.
Positive_regulation (upregulation) of Plaur in extracellular matrix associated with diabetes mellitus and injury
1) Confidence 0.56 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.79 Pain Relevance 0.03
Integrins are essential uPAR signaling co-receptors and the interactions between uPAR/?
Positive_regulation (essential) of uPAR
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 1.23 Pain Relevance 0
With the exception of pla2G1b, these results indicate that treatment of wild type mice with PAR1- and PAR2-AP induced up-regulation of the following PAR1-dependent genes: actb, akt2, arf6, ccl7, cd63, dusp1, fkbp1a, nfkbia, phlda1, plaur, s100a10, tnfaip3, ube2h, and upk2.


Positive_regulation (induced) of plaur
3) Confidence 0.30 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.49 Pain Relevance 0.09
Various reports have demonstrated that cathepsin B and uPAR levels are overexpressed during glioma progression [28]–[30].
Positive_regulation (overexpressed) of uPAR associated with glioma
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.78 Pain Relevance 0
Expression of p27Kip1 is influenced by the upregulation of FOXO3a proteins in cathepsin B and uPAR depleted cells
Positive_regulation (upregulation) of uPAR
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
Since we observed p27Kip1 upregulation with decreased cell proliferation and G0/G1 phase arrest with the depletion of cathepsin B and uPAR, we next determined the expression of FOXO proteins, which are important transcriptional regulators of the p27Kip1 promoter.
Positive_regulation (upregulation) of uPAR
6) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
Visual analog pain score reduction correlated with changes in uPA and uPAR levels as well as uPA activity.
Positive_regulation (changes) of uPAR
7) Confidence 0.05 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.11 Pain Relevance 0
As observed for the MMPs, the extent of induction of the urokinase receptor gene was higher in MEK2DD-expressing cells.
Positive_regulation (induction) of urokinase receptor gene associated with metalloproteinase
8) Confidence 0.02 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.12 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox