INT166575

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 4.00
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Plaur) plasma membrane (Plaur) enzyme binding (Plaur)
kinase activity (Plaur)
Plaur (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 18 100.00 Very High Very High Very High
Osteoarthritis 2 50.00 Quite Low
cINOD 4 5.00 Very Low Very Low Very Low
Perioperative pain 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Inward rectifier potassium channel 1 5.00 Very Low Very Low Very Low
Snapping jaw 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 137 100.00 Very High Very High Very High
Cancer 250 99.84 Very High Very High Very High
Metastasis 31 86.40 High High
Colon Cancer 98 84.96 Quite High
Adhesions 40 70.00 Quite High
Intestinal Cancer 16 68.76 Quite High
Glioblastoma 11 65.60 Quite High
Targeted Disruption 8 56.24 Quite High
Osteoarthritis 2 53.12 Quite High
Temporomandibular Joint Syndrome 1 52.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of shRNA constructs on MMP-9, uPAR, and cathepsin B
Regulation (Effect) of uPAR
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904700 Disease Relevance 0.31 Pain Relevance 0
Immunohistochemical analysis of the tumor sections from control mice for cathepsin B and uPAR showed increased expression levels localized to the tumor region while the pCU-treated tumor sections revealed very little or no expression of the cathepsin B and uPAR.
Regulation (control) of uPAR associated with cancer
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.66 Pain Relevance 0
Cathepsin B and urokinase-type plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas and, as such, are attractive targets for gene therapy.
Regulation (targets) of uPAR associated with glioma
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.86 Pain Relevance 0
To gain insight into the molecular roles of cathepsin B and uPAR, we knocked down the expression of these molecules using shRNA in SNB19 and U251 glioma cells and then analyzed the effects on cell proliferation and cell cycle.
Regulation (roles) of uPAR associated with glioma
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.22 Pain Relevance 0
Cathepsin B and urokinase-type plasminogen activator receptor (uPAR) are both known to be overexpressed in gliomas and, as such, are attractive targets for gene therapy.
Regulation (targets) of urokinase-type plasminogen activator receptor associated with glioma
5) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.86 Pain Relevance 0
Visual analog pain score reduction correlated with changes in uPA and uPAR levels as well as uPA activity.
Regulation (changes) of uPAR
6) Confidence 0.02 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.11 Pain Relevance 0
This was associated with a more prominent down-regulation of E-cadherin and a stronger up-regulation of MMPs and urokinase receptor.
Regulation (regulation) of urokinase receptor associated with metalloproteinase
7) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.65 Pain Relevance 0.05
Because of the importance of MMPs and urokinase receptor in tumor progression [43,44], we further validated the regulation of these genes by MEK1 and MEK2 signaling to confirm the data from the arrays.
Regulation (importance) of urokinase receptor associated with cancer and metalloproteinase
8) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.33 Pain Relevance 0.18

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