INT16659

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Context Info
Confidence 0.64
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 34
Total Number 37
Disease Relevance 6.10
Pain Relevance 11.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eef1a1) translation (Eef1a1) GTPase activity (Eef1a1)
cytoplasm (Eef1a1)
Anatomy Link Frequency
monocytes 3
neurons 3
macrophages 2
dendrites 1
tail 1
Eef1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 78 100.00 Very High Very High Very High
Inflammation 68 100.00 Very High Very High Very High
agonist 50 100.00 Very High Very High Very High
Clonidine 29 100.00 Very High Very High Very High
intrathecal 3 99.98 Very High Very High Very High
chemokine 4 99.88 Very High Very High Very High
noradrenaline 18 99.84 Very High Very High Very High
opiate 3 99.72 Very High Very High Very High
long-term potentiation 9 99.58 Very High Very High Very High
tetrodotoxin 30 99.54 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 70 100.00 Very High Very High Very High
Repression 2 98.68 Very High Very High Very High
Neuropathic Pain 57 97.64 Very High Very High Very High
Nervous System Injury 42 96.20 Very High Very High Very High
Injury 29 93.40 High High
Acute Myeloid Leukemia 4 92.24 High High
Heart Rate Under Development 7 92.00 High High
Experimental Autoimmune Neuritis 2 89.80 High High
Leukemia 5 89.28 High High
Increased Venous Pressure Under Development 2 88.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results show that high K+ exposure increased both alpha 1 and M1 receptor expression regardless of the presence of receptor agonists or antagonists.
Gene_expression (expression) of alpha 1 associated with antagonist and agonist
1) Confidence 0.64 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9298232 Disease Relevance 0 Pain Relevance 0.60
We approached this by comparing the effects of treatment with the alpha 1 adrenoreceptor antagonist prazosin and M1 muscarinic receptor antagonist pirenzepine on the expression of alpha 1 and M1 receptors in cultured cortical neurons.
Gene_expression (expression) of alpha 1 in neurons associated with antagonist
2) Confidence 0.64 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9298232 Disease Relevance 0 Pain Relevance 0.18
In these experiments we compared the effects of high K+, tetrodotoxin (TTX), prazosin, and noradrenaline on the expression of alpha 1 and M1 receptors in cultured neurons.
Gene_expression (expression) of alpha 1 in neurons associated with tetrodotoxin and noradrenaline
3) Confidence 0.64 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9298232 Disease Relevance 0 Pain Relevance 0.62
We found that expression of the alpha 1 receptor is regulated both by neuronal excitability and by the usage of the receptor itself.
Gene_expression (expression) of alpha 1 in neuronal associated with neuronal excitability
4) Confidence 0.64 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9298232 Disease Relevance 0 Pain Relevance 0.17
On the other hand, TTX exposure reduced both alpha 1 and M1 receptor expression regardless of the presence of the receptor agonists or antagonists.
Gene_expression (expression) of alpha 1 associated with tetrodotoxin, antagonist and agonist
5) Confidence 0.64 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9298232 Disease Relevance 0 Pain Relevance 0.57
Conversely blockade of alpha 1 receptors up-regulated alpha 1 expression but not muscarinic receptor expression.
Gene_expression (expression) of alpha 1
6) Confidence 0.56 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9298232 Disease Relevance 0 Pain Relevance 0.39
This implies that the expression levels of M1 and alpha 1 receptors are both regulated through specific signal transduction pathways.
Gene_expression (expression) of alpha 1
7) Confidence 0.56 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9298232 Disease Relevance 0 Pain Relevance 0.46
Developmental expression and regulation of alpha 1 adrenergic receptors in cultured cortical neurons.
Gene_expression (expression) of alpha 1 in neurons
8) Confidence 0.56 Published 1997 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 9298232 Disease Relevance 0 Pain Relevance 0.16
The results showed that blockade of muscarinic receptors with pirenzepine up-regulated muscarinic receptor expression selectively without changing alpha 1 receptor expression.
Gene_expression (expression) of alpha 1
9) Confidence 0.56 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9298232 Disease Relevance 0 Pain Relevance 0.33
The expression and distribution of alpha 1 receptors in cultured neurons derived from rat visual cortex were studied with confocal microscopy using the fluorescently labeled alpha 1 adrenergic receptor selective antagonist BODIPY FL prazosin.
Gene_expression (expression) of alpha 1 in cortex associated with antagonist
10) Confidence 0.56 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9298232 Disease Relevance 0 Pain Relevance 0.11
Based on the potency ratio between alpha-1 and alpha-2 blocking activities, DHC or YO was most selective for alpha-1 or alpha-2 subtype, respectively, among the four YO analogs.
Gene_expression (selective) of alpha-1 associated with potency
11) Confidence 0.52 Published 1990 Journal Chem. Pharm. Bull. Section Abstract Doc Link 1976443 Disease Relevance 0 Pain Relevance 0.38
This effect is blocked by rapamycin, indicating that the increase in eEF1A expression is mediated by mTOR pathway.
Gene_expression (expression) of eEF1A
12) Confidence 0.51 Published 2010 Journal The Journal of Pain Section Body Doc Link PMC3000494 Disease Relevance 0.35 Pain Relevance 0.20
In acute brain slices it has been shown that that the induction of protein synthesis-dependent hippocampal LTP increases the local expression of elongation factor 1A (eEF1A) in dendrites that are severed from their cell bodies before stimulation.
Gene_expression (expression) of eEF1A in dendrites associated with long-term potentiation
13) Confidence 0.51 Published 2010 Journal The Journal of Pain Section Body Doc Link PMC3000494 Disease Relevance 0.31 Pain Relevance 0.20
Remarkably, eEF1A levels increase within 5 minutes after stimulation in a translation-dependent manner, and this effect remains stable for 3 hours.36

Conclusions

Gene_expression (levels) of eEF1A
14) Confidence 0.51 Published 2010 Journal The Journal of Pain Section Body Doc Link PMC3000494 Disease Relevance 0.36 Pain Relevance 0.20
Response of alpha 1- and alpha 2-adrenoceptors was evoked with 6 incremental doses (10(-9) to 10(-4) M) of preferential alpha 1-agonist, phenylephrine and alpha 2-agonist, clonidine respectively. alpha 1-Adrenoceptors were also evoked by phenylephrine after blockade of alpha 2-adrenoceptors with 10(-7) M yohimbine.
Gene_expression (evoked) of alpha 1 associated with agonist and clonidine
15) Confidence 0.50 Published 1987 Journal Artery Section Abstract Doc Link 2823747 Disease Relevance 0.15 Pain Relevance 0.37
Synergism of alpha 1, alpha 2, and beta were required for full antinatriuresis.
Gene_expression (Synergism) of alpha 1
16) Confidence 0.47 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 3028153 Disease Relevance 0.09 Pain Relevance 0.11
The regional distribution of both alpha 1 and alpha 2 adrenoceptors in spinal cord compares to the localization previously classified functionally utilizing various pharmacological agonists and antagonists at norepinephrine receptors.
Gene_expression (distribution) of alpha 1 in spinal cord associated with antagonist, agonist and spinal cord
17) Confidence 0.46 Published 1988 Journal Brain Res. Section Abstract Doc Link 2836025 Disease Relevance 0.37 Pain Relevance 0.39
Selective distribution of alpha-1 and beta adrenoceptors in pregnant rat uterus visualized by autoradiography.
Gene_expression (distribution) of alpha-1 in uterus
18) Confidence 0.42 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1847211 Disease Relevance 0 Pain Relevance 0.21
The rank order of potency of these compounds as alpha-1 antagonists was prazosin greater than phentolamine greater than mianserin greater than yohimbine greater than napamezole greater than idazoxan.
Gene_expression (antagonists) of alpha-1 associated with antagonist and potency
19) Confidence 0.22 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1974637 Disease Relevance 0 Pain Relevance 0.45
Rauwolscine was more potent than RX 781094 in blocking these alpha-2 adrenoceptors in vivo, whereas both compounds were equipotent at alpha-1 adrenoceptors.
Gene_expression (equipotent) of alpha-1
20) Confidence 0.20 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6142941 Disease Relevance 0.09 Pain Relevance 0.34

General Comments

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