INT166590

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 0.39
Pain Relevance 4.80

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protein transporter activity (RAMP1) extracellular space (RAMP1) nucleus (DCLK3)
plasma membrane (RAMP1) cytoplasm (DCLK3)
RAMP1 (Homo sapiens)
DCLK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 1380 99.64 Very High Very High Very High
Neuropeptide 211 98.88 Very High Very High Very High
antagonist 77 94.60 High High
Migraine 9 87.60 High High
headache 8 86.88 High High
agonist 79 75.00 Quite High
Potency 99 66.80 Quite High
Disease Link Frequency Relevance Heat
Migraine Disorders 9 87.60 High High
Neuroblastoma 7 81.12 Quite High
Disease 21 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 14 5.00 Very Low Very Low Very Low
Heart Disease 7 5.00 Very Low Very Low Very Low
Hypertension 7 5.00 Very Low Very Low Very Low
Reperfusion Injury 7 5.00 Very Low Very Low Very Low
Stroke 7 5.00 Very Low Very Low Very Low
Heat Stress Disorders 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The calcitonin receptor-like receptor (CLR) associates with the accessory protein RAMP1 to form a receptor for the neuropeptide calcitonin gene-related peptide (CGRP).
RAMP1 Binding (associates) of CLR associated with neuropeptide and calcitonin gene-related peptide
1) Confidence 0.37 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20188075 Disease Relevance 0.15 Pain Relevance 0.66
A model illustrating this interaction of specific CGRP domains with the CLR-RAMP1 heterodimer (i.e., mature CGRP receptor) is presented in figure 1.
RAMP1 Binding (heterodimer) of CLR associated with calcitonin gene-related peptide
2) Confidence 0.12 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.44
These observations not only indicate the specificity of BIBN4096BS for the mature CLR-RAMP1 heterodimer but suggest that important high-affinity binding contacts on the mature receptor complex maybe common between BIBN4096BS and CGRP.
RAMP1 Binding (heterodimer) of CLR associated with calcitonin gene-related peptide
3) Confidence 0.12 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0.08 Pain Relevance 0.69
These observations not only indicate the specificity of BIBN4096BS for the mature CLR-RAMP1 heterodimer but suggest that important high-affinity binding contacts on the mature receptor complex maybe common between BIBN4096BS and CGRP.
RAMP1 Binding (heterodimer) of CLR associated with calcitonin gene-related peptide
4) Confidence 0.12 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0.08 Pain Relevance 0.69
A model illustrating this interaction of specific CGRP domains with the CLR-RAMP1 heterodimer (i.e., mature CGRP receptor) is presented in figure 1.
RAMP1 Binding (heterodimer) of CLR associated with calcitonin gene-related peptide
5) Confidence 0.12 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.44
Increasing amounts of CGRP(1–36) was able to generate cAMP in HEK293T-RAMP1 cells transiently expressing the wild type CLR in a concentration-dependent manner (Fig 4B) The EC50 of CGRP(1–36) for the expressed wild type CLR-RAMP1 heterodimer was calculated to be 4.3 ± 0.8?
RAMP1 Binding (heterodimer) of CLR associated with calcitonin gene-related peptide
6) Confidence 0.11 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.57
Increasing amounts of CGRP(1–36) was able to generate cAMP in HEK293T-RAMP1 cells transiently expressing the wild type CLR in a concentration-dependent manner (Fig 4B) The EC50 of CGRP(1–36) for the expressed wild type CLR-RAMP1 heterodimer was calculated to be 4.3 ± 0.8?
RAMP1 Binding (heterodimer) of CLR associated with calcitonin gene-related peptide
7) Confidence 0.11 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.57
Consequently, it is reasonable to assume that interactions of CGRP-F37 with the mature CLR-RAMP1 heterodimer would necessitate a more complex relationship in order to account for the high affinity binding associated with the loss of this C-terminal peptide residue.
RAMP1 Binding (heterodimer) of CLR associated with calcitonin gene-related peptide
8) Confidence 0.11 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0.07 Pain Relevance 0.73

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