INT166592

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.33
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA, RAMP1) aging (CALCA) intracellular (CALCA)
cell-cell signaling (CALCA) cytoplasm (CALCA) protein transporter activity (RAMP1)
CALCA (Homo sapiens)
RAMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 792 100.00 Very High Very High Very High
Neuropeptide 121 100.00 Very High Very High Very High
Migraine 6 93.36 High High
headache 5 92.64 High High
antagonist 47 85.52 High High
agonist 46 75.00 Quite High
Potency 57 66.80 Quite High
Disease Link Frequency Relevance Heat
Migraine Disorders 6 93.36 High High
Disease 12 89.48 High High
Neuroblastoma 4 74.00 Quite High
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Heart Disease 4 5.00 Very Low Very Low Very Low
Hypertension 4 5.00 Very Low Very Low Very Low
Reperfusion Injury 4 5.00 Very Low Very Low Very Low
Stroke 4 5.00 Very Low Very Low Very Low
Heat Stress Disorders 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, it is reasonable to assume that interactions of CGRP-F37 with the mature CLR-RAMP1 heterodimer would necessitate a more complex relationship in order to account for the high affinity binding associated with the loss of this C-terminal peptide residue.
CGRP-F37 Binding (heterodimer) of RAMP1 associated with calcitonin gene-related peptide
1) Confidence 0.35 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0.07 Pain Relevance 0.74
A model illustrating this interaction of specific CGRP domains with the CLR-RAMP1 heterodimer (i.e., mature CGRP receptor) is presented in figure 1.
CGRP Binding (interaction) of RAMP1 associated with calcitonin gene-related peptide
2) Confidence 0.35 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.44
The calcitonin receptor-like receptor (CLR) associates with the accessory protein RAMP1 to form a receptor for the neuropeptide calcitonin gene-related peptide (CGRP).
gene-related peptide Binding (associates) of RAMP1 associated with neuropeptide and calcitonin gene-related peptide
3) Confidence 0.27 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20188075 Disease Relevance 0.16 Pain Relevance 0.72
Previous studies on the calcitonin-like receptor (CLR), which requires co-expression of the receptor-activity-modifying protein-1 (RAMP1) to function as a CGRP receptor, have shown an 18 amino acid N-terminus sequence important for binding CGRP.
CGRP Binding (receptor) of RAMP1 associated with calcitonin gene-related peptide
4) Confidence 0.26 Published 2006 Journal BMC Pharmacol Section Abstract Doc Link PMC1525162 Disease Relevance 0.09 Pain Relevance 0.43
Increasing amounts of CGRP(1–36) was able to generate cAMP in HEK293T-RAMP1 cells transiently expressing the wild type CLR in a concentration-dependent manner (Fig 4B) The EC50 of CGRP(1–36) for the expressed wild type CLR-RAMP1 heterodimer was calculated to be 4.3 ± 0.8?
CGRP Binding (heterodimer) of RAMP1 associated with calcitonin gene-related peptide
5) Confidence 0.23 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.58

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox