INT166595

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.18
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (RAMP1) extracellular space (RAMP1) plasma membrane (RAMP1)
RAMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 17 99.60 Very High Very High Very High
Calcitonin gene-related peptide 204 99.22 Very High Very High Very High
Migraine 3 94.12 High High
headache 2 82.88 Quite High
Neuropeptide 31 80.72 Quite High
agonist 13 75.00 Quite High
Potency 15 68.00 Quite High
Disease Link Frequency Relevance Heat
Migraine Disorders 3 94.12 High High
Disease 3 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Heart Disease 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Reperfusion Injury 1 5.00 Very Low Very Low Very Low
Stroke 1 5.00 Very Low Very Low Very Low
Heat Stress Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous work has shown the extracellular portion of RAMP1 to be important for binding of these antagonists, with tryptophan-74 being a key interaction site.
Positive_regulation (important) of RAMP1 Binding (binding) of associated with antagonist
1) Confidence 0.45 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20188075 Disease Relevance 0.18 Pain Relevance 0.79
Increasing amounts of CGRP(1–36) was able to generate cAMP in HEK293T-RAMP1 cells transiently expressing the wild type CLR in a concentration-dependent manner (Fig 4B) The EC50 of CGRP(1–36) for the expressed wild type CLR-RAMP1 heterodimer was calculated to be 4.3 ± 0.8?
Positive_regulation (calculated) of RAMP1 Binding (heterodimer) of associated with calcitonin gene-related peptide
2) Confidence 0.36 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1525162 Disease Relevance 0 Pain Relevance 0.57

General Comments

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